1,3,5-Triazine-azole Hybrids and their Anticancer Activity
| Autor: | Hua Guo, Quan-Ping Diao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Azoles
chemistry.chemical_classification Molecular Structure Cell Survival Triazines 010405 organic chemistry Antineoplastic Agents General Medicine Pharmacology 01 natural sciences 0104 chemical sciences Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry 1 3 5-Triazine In vivo 030220 oncology & carcinogenesis Drug Discovery Humans Structure–activity relationship Azole Drug Screening Assays Antitumor Cell Proliferation |
| Zdroj: | Current Topics in Medicinal Chemistry. 20:1481-1492 |
| ISSN: | 1568-0266 |
| DOI: | 10.2174/1568026620666200310122741 |
| Popis: | 1,3,5-Triazine and azole can interact with various therapeutic targets, and their derivatives possess promising in vitro and in vivo anticancer activity. Hybrid molecules have the potential to enhance efficiency, overcome drug resistance and reduce side effects, and many hybrid molecules are under different phases of clinical trials, so hybridization of 1,3,5-triazine with azole may provide valuable therapeutic intervention for the treatment of cancer. Substantial efforts have been made to develop azole-containing 1,3,5-triazine hybrids as novel anticancer agents, and some of them exhibited excellent activity. This review emphasizes azole-containing 1,3,5-triazine hybrids with potential anticancer activity, and the structure-activity relationships as well as the mechanisms of action are also discussed to provide comprehensive and target-oriented information for the development of this kind of anticancer drugs. |
| Databáze: | OpenAIRE |
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