Role of regenerating islet-derived proteins in inflammatory bowel disease
| Autor: | Alexander Schwartzman, Chongmin Huan, Peiqi Ou, Vladimir Zinsou, Nicholas E Tan, Jodi-Ann Edwards, Sean Roudnitsky, Nadlie Toussaint, Michelle Sagal, Cathy M. Mueller, Lisa Dresner, Albert Stanek |
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| Rok vydání: | 2020 |
| Předmět: |
Crohn’s disease
Colon Enteroendocrine Cells Pancreatitis-Associated Proteins Review Intestinal bacteria Interleukin-22 Inflammatory bowel disease Interleukin 22 Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Crohn Disease medicine Humans Intestinal Mucosa Gastrointestinal tract Crohn's disease business.industry Interleukins Gastroenterology General Medicine medicine.disease Ulcerative colitis Intestinal epithelium digestive system diseases 030220 oncology & carcinogenesis Regenerating islet-derived proteins Immunology Colitis Ulcerative 030211 gastroenterology & hepatology business |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v26.i21.2702 |
| Popis: | Inflammatory bowel disease (IBD) is an inflammatory disorder of the gastrointestinal tract that affects millions of patients worldwide. It has a complex and multifactorial etiology leading to excessive exposure of intestinal epithelium to microbial antigens, inappropriate activation of the immune system and ultimately to the damage of intestinal tissues. Although numerous efforts have been made to improve the disease management, IBD remains persistently recurring and beyond cure. This is due largely to the gaps in our understanding of the pathogenesis of IBD that hamper the development of timely diagnoses and effective treatment. However, some recent discoveries, including the beneficial effects of interleukin-22 (IL-22) on the inflamed intestine, have shed light on a self-protective mechanism in IBD. Regenerating islet-derived (REG/Reg) proteins are small secretory proteins which function as IL-22's downstream effectors. Mounting studies have demonstrated that IBD patients have significantly increased REG expressions in the injured intestine, but with undefined mechanisms and roles. The reported functions of REG/Reg proteins in intestinal homeostasis, such as those of antibacterial, anti-inflammatory and tissue repair, lead us to discuss their potential mechanisms and clinical relevance in IBD in order to advance IBD research and management. |
| Databáze: | OpenAIRE |
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