Patients With Coronary Endothelial Dysfunction Have Impaired Cholesterol Efflux Capacity and Reduced HDL Particle Concentration
| Autor: | Amir Lerman, Angela Irwin, Chongren Tang, Jeffrey S. Monette, Baohai Shao, Jaskanwal D. Sara, Graziella E. Ronsein, Jay W. Heinecke, Patrick M. Hutchins, Jake Wimberger, Tomas Vaisar |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Physiology 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine HDL particle Endothelial dysfunction Coronary atherosclerosis business.industry Cholesterol Case-control study medicine.disease DOENÇAS CARDIOVASCULARES 030104 developmental biology Endocrinology chemistry lipids (amino acids peptides and proteins) Efflux Cardiology and Cardiovascular Medicine business Lipoprotein |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1524-4571 0009-7330 |
| DOI: | 10.1161/circresaha.116.308357 |
| Popis: | Rationale: Coronary endothelial dysfunction (ED)—an early marker of atherosclerosis—increases the risk of cardiovascular events. Objective: We tested the hypothesis that cholesterol efflux capacity and high-density lipoprotein (HDL) particle concentration predict coronary ED better than HDL-cholesterol (HDL-C). Methods and Results: We studied 80 subjects with nonobstructive (IMA ) were assessed with validated assays. Cholesterol efflux capacity and HDL-P IMA were both strong, inverse predictors of ED ( P P =0.005). After correction for HDL-C, both efflux capacity and HDL-P IMA remained significant predictors of ED status. HDL-P IMA explained cholesterol efflux capacity more effectively than HDL-C ( r =0.54 and 0.36, respectively). The efflux capacities of isolated HDL and serum HDL correlated strongly ( r =0.49). Conclusions: Cholesterol efflux capacity and HDL-P IMA are reduced in subjects with coronary ED, independently of HDL-C. Alterations in HDL-P IMA and HDL itself account for a much larger fraction of the variation in cholesterol efflux capacity than does HDL-C. A selective decrease in large HDL particles may contribute to impaired cholesterol efflux capacity in ED subjects. These observations support a role for HDL size, concentration, and function as markers—and perhaps mediators—of coronary atherosclerosis in humans. |
| Databáze: | OpenAIRE |
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