The genome of a Mesozoic paleovirus reveals the evolution of hepatitis B viruses
| Autor: | Jan Ole Kriegs, Alexander Suh, Juergen Schmitz, Juergen Brosius |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Hepatitis B virus
Time Factors viruses Molecular Sequence Data General Physics and Astronomy Genome Viral medicine.disease_cause Genome General Biochemistry Genetics and Molecular Biology Phylogenetics medicine Animals Conserved Sequence Phylogeny Mammals Multidisciplinary Base Sequence biology Phylogenetic tree Host (biology) Paleontology Bayes Theorem General Chemistry Hepatitis B biology.organism_classification medicine.disease Biological Evolution Virology Mutagenesis Insertional Amino Acid Substitution Hepadnaviridae Evolutionary biology Finches Paleovirology |
| Zdroj: | Nature Communications. 4 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms2798 |
| Popis: | Paleovirology involves the identification of ancient endogenous viral elements within eukaryotic genomes. The evolutionary origins of the reverse-transcribing hepatitis B viruses, however, remain elusive, due to the small number of endogenized sequences present in host genomes. Here we report a comprehensively dated genomic record of hepatitis B virus endogenizations that spans bird evolution from82 to12.1 million years ago. The oldest virus relic extends over a 99% complete hepatitis B virus genome sequence and constitutes the first discovery of a Mesozoic paleovirus genome. We show that Hepadnaviridae are63 million years older than previously known and provide direct evidence for coexistence of hepatitis B viruses and birds during the Mesozoic and Cenozoic Eras. Finally, phylogenetic analyses and distribution of hepatitis B virus relics suggest that birds potentially are the ancestral hosts of Hepadnaviridae and mammalian hepatitis B viruses probably emerged after a bird-mammal host switch. Our study reveals previously undiscovered and multi-faceted insights into prehistoric hepatitis B virus evolution and provides valuable resources for future studies, such as in-vitro resurrection of Mesozoic hepadnaviruses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|