Production of oil-containing polyterephthalamide microcapsules by interfacial polymerization. An experimental investigation of the effect of process variables on the microcapsule size distribution
| Autor: | S. Alexandridou, Costas Kiparissides |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Vinyl alcohol
Materials science Chemical Phenomena Polymers Surface Properties Chemistry Pharmaceutical Drug Compounding Pharmaceutical Science Ionic bonding Bioengineering Capsules Phthalimides Dosage form chemistry.chemical_compound Surface-Active Agents Colloid and Surface Chemistry Drug Stability Phase (matter) Polymer chemistry Physical and Theoretical Chemistry Particle Size Chemistry Physical Viscosity Organic Chemistry Interfacial polymerization Toluene Chemical engineering chemistry Oil droplet Polyvinyl Alcohol Emulsions Oils Stabilizer (chemistry) |
| Zdroj: | Journal of microencapsulation. 11(6) |
| ISSN: | 0265-2048 2000-7000 |
| Popis: | Oil-containing polyterephthalamide microcapsules were prepared by the interfacial polymerization technique. The inner phase of the microcapsules consisted of a mixture of an organic solvent, toluene, and a commercial oil, santosol. Microcapsules with mean Sauter diameters in the range 0.5-20 microns were prepared by varying the rate of agitation (2000-7000 rpm) and the concentration of a poly(vinyl alcohol) stabilizer (0.1-1.0 wt% w/v), in the presence of several ionic and non-ionic cosurfactants. High agitation rates resulted in a significant reduction of the mean size of the oil droplets, although a slight increase in the breadth of the droplet size distribution was observed. High concentrations of PVA also resulted in a decrease of the microcapsule size, although the effect of stabilizer concentration was generally less important than that of the agitation speed. Finally, the effect of various ionic and non-ionic cosurfactants on the microcapsule size distribution was investigated. It was found that the addition of a cosurfactant significantly reduced the mean droplet size of the initial emulsion, leading to the formation of microcapsules in the submicron range. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|