Sensitivity of a two-dimensional biomorphoelastic model for post-burn contraction

Autor: Ginger Egberts, Alexis Desmoulière, Fred Vermolen, Paul van Zuijlen
Přispěvatelé: Plastic, Reconstructive and Hand Surgery, AMS - Tissue Function & Regeneration, Paediatric Surgery, EGBERTS, Ginger, Desmouliere, Alexis, VERMOLEN, Fred, van Zuijlen, Paul
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Egberts, G, Desmoulière, A, Vermolen, F & van Zuijlen, P 2022, ' Sensitivity of a two-dimensional biomorphoelastic model for post-burn contraction ', Biomechanics and Modeling in Mechanobiology . https://doi.org/10.1007/s10237-022-01634-w
Biomechanics and Modeling in Mechanobiology. Springer Verlag
Biomechanics and Modeling in Mechanobiology (online), 22(1)
ISSN: 1617-7959
Popis: We consider a two-dimensional biomorphoelastic model describing post-burn scar contraction. This model describes skin displacement and the development of the effective Eulerian strain in the tissue. Besides these mechanical components, signaling molecules, fibroblasts, myofibroblasts, and collagen also play a significant role in the model. We perform a sensitivity analysis for the independent parameters of the model and focus on the effects on features of the relative surface area and the total strain energy density. We conclude that the most sensitive parameters are the Poisson's ratio, the equilibrium collagen concentration, the contraction inhibitor constant, and the myofibroblast apoptosis rate. Next to these insights, we perform a sensitivity analysis where the proliferation rates of fibroblasts and myofibroblasts are not the same. The impact of this model adaptation is significant. This project is funded by the Dutch Burns Foundation under Project 17.105 The authors are grateful for the fnancial support from the Dutch Burns Foundation under Project 17.105.
Databáze: OpenAIRE
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