Outbreak of Listeriosis in South Africa Associated with Processed Meat
| Autor: | Vivien Essel, A.M. Shonhiwa, Kerrigan McCarthy, Tim Doyle, Nomsa P. Tau, Deon Mahoney, Alexandre Leclercq, Genevie Ntshoe, Olivier Disson, Mushal Allam, Robert W. Stewart, Adriano Duse, Mylène M. Maury, Teena Thomas, Hlengiwe M Ngomane, Linda Erasmus, Marc Lecuit, Arshad Ismail, Mathieu Tourdjman, Anthony M. Smith, Pierre Thouvenot, Juno Thomas, Bolele Disenyeng, Ntsieni Ramalwa, N. Govender, Lucille Blumberg, Nelesh P. Govender, Phuti Sekwadi, Shannon L. Smouse, Nicola Page |
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| Přispěvatelé: | National Institute for Communicable Diseases [Johannesburg] (NICD), University of the Witwatersrand [Johannesburg] (WITS), Santé publique France - French National Public Health Agency [Saint-Maurice, France], Biologie des Infections - Biology of Infection, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de Référence Listeria - National Reference Center Listeria (CNRL), Centre collaborateur de l'OMS Listeria / WHO Collaborating Centre Listeria (CC-OMS / WHO-CC), Institut Pasteur [Paris]-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Université de Paris (UP), Service des Maladies infectieuses et tropicales [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] (IP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Université Paris Cité (UPCité) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Adolescent [SDV]Life Sciences [q-bio] HIV Infections 030204 cardiovascular system & hematology Article Disease Outbreaks Foodborne Diseases South Africa Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Environmental health Humans Medicine Listeriosis Processed meat 030212 general & internal medicine Pregnancy Complications Infectious Sex Distribution Aged Whole Genome Sequencing business.industry Infant Newborn Outbreak General Medicine Middle Aged Listeria monocytogenes Bacterial Typing Techniques 3. Good health Meat Products Product Recalls and Withdrawals Case-Control Studies Food borne HIV-1 Female [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | New England Journal of Medicine New England Journal of Medicine, Massachusetts Medical Society, 2020, 382 (7), pp.632-643. ⟨10.1056/NEJMoa1907462⟩ New England Journal of Medicine, 2020, 382 (7), pp.632-643. ⟨10.1056/NEJMoa1907462⟩ N Engl J Med |
| ISSN: | 0028-4793 1533-4406 |
| DOI: | 10.1056/NEJMoa1907462⟩ |
| Popis: | International audience; BackgroundAn outbreak of listeriosis was identified in South Africa in 2017. The source was unknown.MethodsWe conducted epidemiologic, trace-back, and environmental investigations and used whole-genome sequencing to type Listeria monocytogenes isolates. A case was defined as laboratory-confirmed L. monocytogenes infection during the period from June 11, 2017, to April 7, 2018.ResultsA total of 937 cases were identified, of which 465 (50%) were associated with pregnancy; 406 of the pregnancy-associated cases (87%) occurred in neonates. Of the 937 cases, 229 (24%) occurred in patients 15 to 49 years of age (excluding those who were pregnant). Among the patients in whom human immunodeficiency virus (HIV) status was known, 38% of those with pregnancy-associated cases (77 of 204) and 46% of the remaining patients (97 of 211) were infected with HIV. Among 728 patients with a known outcome, 193 (27%) died. Clinical isolates from 609 patients were sequenced, and 567 (93%) were identified as sequence type 6 (ST6). In a case–control analysis, patients with ST6 infections were more likely to have eaten polony (a ready-to-eat processed meat) than those with non-ST6 infections (odds ratio, 8.55; 95% confidence interval, 1.66 to 43.35). Polony and environmental samples also yielded ST6 isolates, which, together with the isolates from the patients, belonged to the same core-genome multilocus sequence typing cluster with no more than 4 allelic differences; these findings showed that polony produced at a single facility was the outbreak source. A recall of ready-to-eat processed meat products from this facility was associated with a rapid decline in the incidence of L. monocytogenes ST6 infections.ConclusionsThis investigation showed that in a middle-income country with a high prevalence of HIV infection, L. monocytogenes caused disproportionate illness among pregnant girls and women and HIV-infected persons. Whole-genome sequencing facilitated the detection of the outbreak and guided the trace-back investigations that led to the identification of the source. |
| Databáze: | OpenAIRE |
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