Osteopontin in the Cerebrospinal Fluid of Patients with Severe Aneurysmal Subarachnoid Hemorrhage
| Autor: | Francesco Della Corte, Gianmaria Cammarota, Nausicaa Clemente, Maria Giulia Abate, Fabio Carfagna, Gian Carlo Avanzi, Umberto Dianzani, Giuseppe Citerio, Giuseppe Cappellano, Rosanna Vaschetto, Lorenza Moretto, Arnaldo Benech, Gabriele Panzarasa, Teresa Esposito, Carlo Olivieri, Lorenzo Capuano, Matteo Brucoli, Ilaria Licari |
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| Přispěvatelé: | Abate, M, Moretto, L, Licari, I, Esposito, T, Capuano, L, Olivieri, C, Benech, A, Brucoli, M, Avanzi, G, Cammarota, G, Dianzani, U, Clemente, N, Panzarasa, G, Citerio, G, Carfagna, F, Cappellano, G, Della Corte, F, Vaschetto, R |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Subarachnoid hemorrhage Population Inflammation Aneurysm Ruptured Gastroenterology Cerebrospinal fluid stomatognathic system Internal medicine medicine Humans Osteopontin cardiovascular diseases education lcsh:QH301-705.5 Aged education.field_of_study biology business.industry Brief Report Intracranial Aneurysm General Medicine Biomarker Middle Aged medicine.disease Prognosis Weak correlation lcsh:Biology (General) biology.protein Biomarker (medicine) Female medicine.symptom business Biomarkers External ventricular drain |
| Zdroj: | Cells, Vol 8, Iss 7, p 695 (2019) Cells |
| Popis: | Aneurysmal subarachnoid hemorrhage (SAH) is associated with high morbidity and mortality. In SAH patients, plasma osteopontin (OPN) has been shown to independently predict poor outcome. The aim of the study is to investigate, in a selected population with severe SAH, OPN time course in cerebrospinal fluid (CSF) and plasma during the first week after aneurism rupture, and OPN prognostic value. We included 44 patients with the following criteria: (1) age 18 and 80 years, (2) diagnosis of SAH from cerebral aneurysm rupture, (3) insertion of external ventricular drain. Plasma and CSF were sampled at day 1, 4, and 8. OPN levels, in CSF and plasma, displayed a weak correlation on day 1 and were higher, in CSF, in all time points. Only in poor prognosis patients, OPN levels in CSF significantly increased at day 4 and day 8. Plasma OPN at day 1 and 4 was predictor of poor outcome. In conclusion, plasma and CSF OPN displays a weak correlation, on day 1. The higher levels of OPN found in the CSF compared to plasma, suggest OPN production within the CNS after SAH. Furthermore, plasma OPN, at day 1 and 4, seems to be an independent predictor of poor outcome. |
| Databáze: | OpenAIRE |
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