Effects of sleep deprivation on human immune functions
| Autor: | Gorczynski R, F A Lue, Harvey Moldofsky, J R Davidson |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone Stimulation Lymphocyte Activation Biochemistry Immune system Internal medicine Genetics medicine Humans Lymphocytes Circadian rhythm Molecular Biology Immunity Cellular business.industry Pokeweed mitogen Lymphokine Interleukin Sleep in non-human animals Circadian Rhythm Killer Cells Natural Sleep deprivation Endocrinology Interleukin-2 Sleep Deprivation medicine.symptom Sleep business Interleukin-1 Biotechnology |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fasebj.3.8.2785942 |
| Popis: | The effect of 40 h of wakefulness on a variety of immunological parameters in the peripheral blood from 10 normal male subjects was studied. Sleep deprivation led to enhanced nocturnal plasma interleukin 1-like and interleukin 2-like activities. The rise in nocturnal response of lymphocytes to pokeweed mitogen stimulation during a normal 24 h sleep-wake cycle was delayed by sleep deprivation, but the response to the phytohemagglutinin mitogen was unaffected. With resumed nocturnal sleep, there was a prolonged decline in natural killer cell activity (measured as spontaneous cytolytic activity for human tumor cells) and return of an increased response to pokeweed mitogen. The altered patterns in immune functions occurred independently of the cortisol circadian rhythm, which remained unchanged. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text