Histopathological Changes in Surrounding Tissue of the Sciatic Nerve after Spinal Cord Injury in Rats

Autor:	Masahiro Hoso, Shinya Yoshida, Yoshitaka Araki, Ikufumi Takahashi, Akio Kamijyo, Taro Matsuzaki, Ippei Kitade
Rok vydání:	2012
Předmět:	Pathology medicine.medical_specialty business.industry Physical Therapy Sports Therapy and Rehabilitation Sciatic nerve Spinal cord injury medicine.disease Perineurium medicine.anatomical_structure medicine Epineurial repair business
Zdroj:	Journal of Physical Therapy Science. 24:817-820
ISSN:	2187-5626 0915-5287
DOI:	10.1589/jpts.24.817
Popis:	[Purpose] The purpose of this study was to examine histopathological changes in tissue surrounding the sciatic nerve after spinal cord injury (SCI) in rats. [Subjects and Methods] Thirty adult, nine-week-old, female Wistar rats were used in this study. Fifteen experimental rats underwent spinal cord transection at the level of Th8-9 and the other fifteen control rats were raised normally. Animals were assessed at 1, 2, 4, 8, and 12 weeks following surgery. After the experimental period, we obtained tissue surrounding the sciatic nerve of the thigh after hematoxylin and eosin staining under a microscope. [Results] Adherence between the nerve bundle and perineural innermost layer was observed in tissue surrounding the sciatic nerve in the SCI group. Adherence among the interperineurium was evident at 2 weeks after SCI. It had declined at 4 weeks after SCI, but was still evident at 8 and 12 weeks after SCI. [Conclusion] Histopathological findings in the SCI model may be related to compression of the nerve bundle and neurogenic contracture of tissue surrounding the nerve bundle. Thesis of Ippei Kitade / 北出 一平 博士論文 金沢大学医薬保健学総合研究科（保健学専攻）
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b26d2450a896496562f99b8b9949c0 https://doi.org/10.1589/jpts.24.817 Zobrazit plný text záznamu