Comparison of pulsed photothermal radiometry, optical coherence tomography and ultrasound for melanoma thickness measurement in PDMS tissue phantoms
| Autor: | Srivalleesha Mallidi, Keith P. Johnston, Jinze Qiu, Jingjing Sun, Thomas E. Milner, Roman V. Kuranov, Tianyi Wang, Li Ma, Amit S. Paranjape |
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| Rok vydání: | 2010 |
| Předmět: |
Skin Neoplasms
Materials science Monte Carlo method General Physics and Astronomy Lateral resolution General Biochemistry Genetics and Molecular Biology Optics Optical coherence tomography medicine Heat transfer model General Materials Science Dimethylpolysiloxanes Radiometry Melanoma Neoplasm Staging Ultrasonography medicine.diagnostic_test Phantoms Imaging business.industry Ultrasound General Engineering General Chemistry medicine.disease Photothermal radiometry business Tomography Optical Coherence |
| Zdroj: | Journal of Biophotonics. 4:335-344 |
| ISSN: | 1864-063X |
| DOI: | 10.1002/jbio.201000078 |
| Popis: | Melanoma accounts for 75% of all skin cancer deaths. Pulsed photothermal radiometry (PPTR), optical coherence tomography (OCT) and ultrasound (US) are non-invasive imaging techniques that may be used to measure melanoma thickness, thus, determining surgical margins. We constructed a series of PDMS tissue phantoms simulating melanomas of different thicknesses. PPTR, OCT and US measurements were recorded from PDMS tissue phantoms and results were compared in terms of axial imaging range, axial resolution and imaging time. A Monte Carlo simulation and three-dimensional heat transfer model was constructed to simulate PPTR measurement. Experimental results show that PPTR and US can provide a wide axial imaging range (75 μm-1.7 mm and 120-910 μm respectively) but poor axial resolution (75 and 120 μm respectively) in PDMS tissue phantoms, while OCT has the most superficial axial imaging range (14-450 μm) but highest axial resolution (14 μm). The Monte Carlo simulation and three-dimensional heat transfer model give good agreement with PPTR measurement. PPTR and US are suited to measure thicker melanoma lesions (>400 μm), while OCT is better to measure thin melanoma lesions ( |
| Databáze: | OpenAIRE |
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