Risk of seizures in children receiving busulphan-containing regimens for stem cell transplantation
| Autor: | Caselli D, Rosati A, Faraci M, Podda M, Ripaldi M, Longoni D, Cesaro S, Lo Nigro L, Paolicchi O, Maximova N, Menconi MC, Ziino O, Cicalese MP, Santarone S, Nesi F, Aricò M, Locatelli F, Prete A, Bone Marrow Transplantation Working Group of the Associazione Italiana Ematologia Oncologia Pediatrica. |
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| Přispěvatelé: | Caselli, D, Rosati, A, Faraci, M, Podda, M, Ripaldi, M, Longoni, D, Cesaro, S, Lo Nigro, L, Paolicchi, O, Maximova, N, Menconi, Mc, Ziino, O, Cicalese, Mp, Santarone, S, Nesi, F, Aricò, M, Locatelli, F, Prete, A, Bone Marrow Transplantation Working Group of the Associazione Italiana Ematologia Oncologia, Pediatrica. |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Busulphan stem cell transplantation Conditioning regimen Epilepsy Young Adult Seizures Medicine Humans Risk factor HEMATOPOIETIC STEM CELL TRASPLANTATION pediatric Child Antineoplastic Agents Alkylating Busulfan Transplantation business.industry Prophylaxis Incidence (epidemiology) Hematopoietic Stem Cell Transplantation seizure prophylaxis Infant Hematology medicine.disease Regimen Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA Child Preschool Brain lesions Female Stem cell business |
| Zdroj: | Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 20(2) |
| ISSN: | 1523-6536 |
| Popis: | Busulphan (BU) is associated with neurotoxicity and risk of seizures. Hence, seizure prophylaxis is routinely utilized during BU administration for stem cell transplantation (SCT). We collected data on the incidence of seizures among children undergoing SCT in Italy. Fourteen pediatric transplantation centers agreed to report unselected data on children receiving BU as part of the conditioning regimen for SCT between 2005 and 2012. Data on 954 pediatric transplantation procedures were collected; of them, 66% of the patients received BU orally, and the remaining 34%, i.v. All the patients received prophylaxis of seizures, according to local protocols, consisting of different schedules and drugs. A total of 13 patients (1.3%) developed seizures; of them, 3 had a history of epilepsy (or other seizure-related pre-existing condition); 3 had documented brain lesions potentially causing seizures per se; 1 had febrile seizures, 1 severe hypo-osmolality. In the remaining 5 patients, seizures were considered not explained and, thus, potentially related to BU administration. The incidence of seizures in children receiving BU-containing regimen was very low (1.3%); furthermore, most of them had at least 1—either pre-existing or concurrent—associated risk factor for seizures. |
| Databáze: | OpenAIRE |
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