Scalp high-frequency oscillation rates are higher in younger children
| Autor: | Santo Pietro Lo Biundo, Dorottya Cserpán, Georgia Ramantani, Ece Boran, Richard E. Rosch, Johannes Sarnthein |
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| Přispěvatelé: | University of Zurich |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty paediatric epilepsy 610 Medicine & health High frequency oscillation Electroencephalography 10180 Clinic for Neurosurgery 03 medical and health sciences Epilepsy 0302 clinical medicine Internal medicine medicine Generalized epilepsy high-frequency oscillations reliability medicine.diagnostic_test Oscillation business.industry General Engineering medicine.disease Scalp eeg 030104 developmental biology medicine.anatomical_structure scalp EEG Scalp Cardiology biomarker Original Article business 030217 neurology & neurosurgery Paediatric population |
| Zdroj: | Brain Communications |
| ISSN: | 2632-1297 |
| Popis: | High-frequency oscillations in scalp EEG are promising non-invasive biomarkers of epileptogenicity. However, it is unclear how high-frequency oscillations are impacted by age in the paediatric population. We prospectively recorded whole-night scalp EEG in 30 children and adolescents with focal or generalized epilepsy. We used an automated and clinically validated high-frequency oscillation detector to determine ripple rates (80–250 Hz) in bipolar channels. Children < 7 years had higher high-frequency oscillation rates (P = 0.021) when compared with older children. The median test−retest reliability of high-frequency oscillation rates reached 100% (iqr 50) for a data interval duration of 10 min. Scalp high-frequency oscillation frequency decreased with age (r = −0.558, P = 0.002), whereas scalp high-frequency oscillation duration and amplitude were unaffected. The signal-to-noise ratio improved with age (r = 0.37, P = 0.048), and the background ripple band activity decreased with age (r = −0.463, P = 0.011). We characterize the relationship of scalp high-frequency oscillation features and age in paediatric patients. EEG intervals of ≥10 min duration are required for reliable measurements of high-frequency oscillation rates. This study is a further step towards establishing scalp high-frequency oscillations as a valid epileptogenicity biomarker in this vulnerable age group. Cserpan et al. report the impact of age on high-frequency oscillations recorded in the scalp EEG of children with epilepsy. Children Graphical Abstract Graphical Abstract |
| Databáze: | OpenAIRE |
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