Different dosages of intravenous immunoglobulin (IVIg) in treating immune thrombocytopenia with long-term follow-up of three years: Results of a prospective study including 167 cases
| Autor: | Huiyuan Li, Feng Xue, Renchi Yang, Zeping Zhou, Xian Zhang, Na Luo, Zhuoqing Qiao |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Pediatrics Adolescent Dose Immunology Dose-Response Relationship Immunologic 030204 cardiovascular system & hematology Gastroenterology Group A Drug Administration Schedule Group B 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Internal medicine Humans Immunologic Factors Immunology and Allergy Medicine Platelet Prospective Studies Child Prospective cohort study Aged Aged 80 and over Purpura Thrombocytopenic Idiopathic biology Platelet Count business.industry Immunoglobulins Intravenous Infant Middle Aged Immune thrombocytopenia Regimen Treatment Outcome Case-Control Studies Child Preschool 030220 oncology & carcinogenesis biology.protein Female Antibody business Follow-Up Studies |
| Zdroj: | Autoimmunity. 49:50-57 |
| ISSN: | 1607-842X 0891-6934 |
| Popis: | This study compared the effects of different dosages of intravenous immunoglobulin (IVIg) against immune thrombocytopenia (ITP). A total of 167 patients, 91 adults and 76 children, with ITP, followed-up for three years in the case-control study, were divided into three subgroups according to the dosages of IVIg administered: group A (0.2 g/kg/day), group B (0.3 g/kg/day) and group C (0.4 g/kg/day). The therapeutic response in 91 adult patients did not differ significantly among the three groups of IVIg dosages (p = 0.459). The response rate of IVIg treatment in the three adult groups was 97.1% for group A, 97.2% for group B and 100% for group C. The mean time for raising platelets to 30 × 10(9)/L in group A was 2.5 days, group B 3.2 days and group C 2.9 days (p = 0.324). The median IVIg consumption in group A was 0.83 g/kg, group B 1.22 g/kg and group C 1.64 g/kg (p |
| Databáze: | OpenAIRE |
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