Tissue expression of human epididymal secretory protein 4 may be useful in the differential diagnosis of uterine cervical tumors
| Autor: | Tuğba Karadeniz, Sevil Sayhan, Fatma Aydiner, Dudu Solakoglu Kahraman, Tulay Akman, Gulden Diniz, Talya Akata, Duygu Ayaz |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine Pathology medicine.medical_specialty Adenosquamous carcinoma Uterine Cervical Neoplasms Adenocarcinoma medicine.disease_cause Diagnosis Differential Carcinoma Adenosquamous Young Adult 03 medical and health sciences WAP Four-Disulfide Core Domain Protein 2 0302 clinical medicine Biomarkers Tumor medicine Humans Neoplasm Neoplasm Invasiveness Aged Tumor marker Aged 80 and over business.industry Proteins Obstetrics and Gynecology Middle Aged Uterine Cervical Dysplasia medicine.disease Immunohistochemistry 030104 developmental biology Secretory protein Tissue expression 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Squamous Intraepithelial Lesions of the Cervix Differential diagnosis Carcinogenesis business |
| Zdroj: | Ginekologia Polska. 88:51-55 |
| ISSN: | 2543-6767 0017-0011 |
| Popis: | Objectives: Human Epididymal Secretory Protein 4 was firstly described as an epididymis-specific protein but more recently it has been demonstrated to be a putative serum tumor marker for different malignancies, especially ovarian epithelial cancers. The aim of this study is to investigate the association between tissue Human Epididymal Secretory Protein 4 expression and the clinicopathological features of uterine cervical tumors. Material and methods: This retrospective study was designed to evaluate the differences of tissue expressions of Human Epididymal Secretory Protein 4 protein in a spectrum of cervical neoplasms. One hundred and seven patients recently diagnosed as having cervical intraepithelial neoplasm or invasive squamous cell carcinoma, adenosquamous carcinoma and adenocarcinoma based on pathology databases. Results: Decreased or negative Human Epididymal Secretory Protein 4 expressions were determined in both normal cervical epithelia and in intraepithelial carcinomas, while increased HE4 expression was observed in invasive tumors. Conclusions: This study demonstrated that altered expression of Human Epididymal Secretory Protein 4 may involve in tumorigenesis in the uterine cervix. Our findings also suggested the presence of a correlation between Human Epididymal Secretory Protein 4 expression and the invasive potential of uterine tumors. Therefore it may be thought that the tissue expression of HE4 can be used to differentiate high grade intraepithelial tumors from carcinomas. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|