Hepatic connective tissue changes in hepatosplenic schistosomiasis
| Autor: | Sylviane Guerret, Zilton de Araújo Andrade, Jean-Alexis Grimaud, Ediriomar Peixoto |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Liver Diseases Parasitic Connective tissue Spleen Schistosomiasis Muscle Smooth Vascular Hepatitis Pathology and Forensic Medicine Laminin medicine Humans Involution (medicine) Splenic Diseases biology Portal Vein Middle Aged Hyperplasia medicine.disease Immunohistochemistry Extracellular Matrix Fibronectin Microscopy Electron medicine.anatomical_structure Chronic Disease biology.protein Female Desmin |
| Zdroj: | Human Pathology. 23:566-573 |
| ISSN: | 0046-8177 |
| DOI: | 10.1016/0046-8177(92)90135-p |
| Popis: | Destruction of intrahepatic portal vein branches with dispersion of smooth muscle cells into the periportal fibrosis and preservation of arterial and ductal structures were the main characteristic findings seen in 66 surgical liver biopsies from patients with the hepatosplenic form of schistosomiasis. Besides these diagnostic features, the present histologic, immunocytochemical, and ultrastructural study revealed the presence of a complex matrix forming the portal and septal fibrosis in advanced schistosomiasis. There was marked hyperplasia of elastic tissue, presence of several collagen isotypes (I, III, procollagen III, IV, and V), actin. desmin, fibronectin, and laminin in a richly vascularized connective tissue. Signs of multifocal matrix (collagen) degradation were observed both at light and electron microscopic levels, suggesting a predominance of a fibrolytic process, at the time parasite-related lesions had almost disappeared. The latter findings are related to the involution of periportal fibrosis now being observed in patients who have undergone antischistosomal chemotherapy. They exemplify morphologic changes connected with chronic collagen degradation in human schistosomiasis that are similar to those first seen in experimental material. Evidence of either persistent or active chronic hepatitis was seen in several cases but its etiology could not be determined. |
| Databáze: | OpenAIRE |
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