Effects of congenital HCMV infection on synaptic plasticity in dentate gyrus (DG) of rat hippocampus
| Autor: | Li Yang, Xiaoyan Xu, De Wu, Di-Yun Ruan, Gong-Chun Zhang, Jiu-Lai Tang, Xi-Song Bu |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Hippocampus Biology Hippocampal formation Rats Sprague-Dawley Calmodulin Internal medicine medicine Animals Molecular Biology Calcium metabolism Neuronal Plasticity Reverse Transcriptase Polymerase Chain Reaction musculoskeletal neural and ocular physiology General Neuroscience Dentate gyrus Excitatory Postsynaptic Potentials Long-term potentiation Immunohistochemistry Rats Endocrinology nervous system Cytomegalovirus Infections Dentate Gyrus Synaptic plasticity Excitatory postsynaptic potential Calcium Neurology (clinical) Analysis of variance Neuroscience Developmental Biology |
| Zdroj: | Brain Research. 1389:27-34 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2011.03.007 |
| Popis: | This study was carried out to investigate whether the congenital HCMV infection affect the induction and maintenance of LTP /DP. Rat models of Sprague-Dawley rats congenitally infected by HCMV were made. Field excitatory postsynaptic potentials (EPSPs) were recorded in the hippocampal slices of offspring rats (50-65days) to study alterations of LTP /DP in area dentate gyrus (DG) of the hippocampus after congenital infection. The Ca(2+) and mRNA level of calmodulin (CaM) in the hippocampus neurons of the experiment group (congenital infected by HCMV) and the control group were measured;The input/output (I/O) curves of the EPSP slope PS amplitude in area DG in experiment group were significantly depressed when compared to control group (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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