Complexity of chromatin folding is captured by the strings and binders switch model
| Autor: | Liron-Mark Lavitas, Mariano Barbieri, Ana Pombo, Josée Dostie, Mita Chotalia, Mario Nicodemi, James Fraser |
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| Přispěvatelé: | M., Barbieri, M., Chotalia, J., Fraser, L. M., Lavita, J., Dostie, A., Pombo, Nicodemi, Mario |
| Rok vydání: | 2012 |
| Předmět: |
Genetics
Genome Multidisciplinary Biological Sciences Biology Chromatin Assembly and Disassembly Chromatin long-range chromatin interaction Domain formation polymer physic Chromosome conformation capture Folding (chemistry) Gene Expression Regulation Models Chemical Computer Simulation genome organization Scaffold/matrix attachment region Biological system Monte Carlo Method In Situ Hybridization Fluorescence Monte Carlo simulation |
| Zdroj: | Proceedings of the National Academy of Sciences. 109:16173-16178 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1204799109 |
| Popis: | Chromatin has a complex spatial organization in the cell nucleus that serves vital functional purposes. A variety of chromatin folding conformations has been detected by single-cell imaging and chromosome conformation capture-based approaches. However, a unified quantitative framework describing spatial chromatin organization is still lacking. Here, we explore the “strings and binders switch” model to explain the origin and variety of chromatin behaviors that coexist and dynamically change within living cells. This simple polymer model recapitulates the scaling properties of chromatin folding reported experimentally in different cellular systems, the fractal state of chromatin, the processes of domain formation, and looping out. Additionally, the strings and binders switch model reproduces the recently proposed “fractal–globule” model, but only as one of many possible transient conformations. |
| Databáze: | OpenAIRE |
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