In sickness and in health: pivotal role of vitamin D
| Autor: | Ivan Bolanča, Marijana Miler, Nora Nikolac Gabaj, Jelena Culej, Adriana Unić, Lara Milevoj Kopcinovic, Alen Vrtarić, Davorka Herman Mahečić, Tomislav Pavičić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Lung Diseases
Male medicine.medical_specialty Vitamin D-binding protein Clinical Biochemistry Jaundice 030209 endocrinology & metabolism vitamin D Hyperlipidemias Urine Review Breast milk Hemolysis vitamin D deficiency Bone remodeling preanalytical variability diabetes mellitus polymorphism fertility extravascular body fluids 03 medical and health sciences 0302 clinical medicine Tandem Mass Spectrometry Internal medicine Diabetes mellitus Neoplasms Rheumatic Diseases medicine Vitamin D and neurology Animals Humans 030304 developmental biology Calcium metabolism 0303 health sciences business.industry Biochemistry (medical) medicine.disease Vitamin D Deficiency Endocrinology Cardiovascular Diseases Female Seasons business Chromatography Liquid |
| Zdroj: | Biochemia Medica Volume 30 Issue 2 |
| ISSN: | 1846-7482 1330-0962 |
| Popis: | Within the last several years, frequency of vitamin D testing has multiplied substantially all over the world, since it has been shown to have an important role in many diseases and conditions. Even though liquid chromatography - tandem mass spectrometry (LC-MS/MS) has been identified as “gold standard” method for vitamin D measurement, most laboratories still use immunochemistry methods. Besides analytical problems (hydrophobicity, low circulating concentrations, ability to bind to lipids, albumins and vitamin D binding protein, presence of multiple vitamin D metabolites and variable ratios of 25(OH)D2 and 25(OH)D3 in the blood), vitamin D shows great preanalytical variability, since its concentration is drastically influenced by seasonal changes, exposure to sun, type of clothes or sun block creams. Vitamin D is mostly measured in serum or plasma, but new studies are showing importance of measuring vitamin D in pleural effusions, breast milk, urine, synovial fluid and saliva. Besides the main role in calcium homeostasis and bone metabolism, many studies linked vitamin D deficiency with cancer, cardiovascular diseases, diabetes, fertility and many other conditions. However, even though initial observational studies indicated that supplementation with vitamin D might be beneficial in disease development and progression; first results of well-designed randomized controlled prospective studies did not find differences in frequency of cardiovascular events or invasive cancer between patients taking vitamin D supplementation compared to placebo. In the light of these recent findings, validity of excessive vitamin D testing remains an open question. |
| Databáze: | OpenAIRE |
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