Short intracortical facilitation associates with motor-inhibitory control
| Autor: | Ying-hua Jing, Yue Lan, Li Wanqi, Qian Ding, Guangqing Xu, Tuo Lin, Tifei Yuan, Guiyuan Cai, Hongying Chen, Huiting Cai, Manfeng Wu |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_treatment Stop signal Impulsivity Executive Function Young Adult 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Inhibitory control medicine Humans 030304 developmental biology 0303 health sciences Electromyography business.industry Motor Cortex Healthy subjects Neural Inhibition Transcranial Magnetic Stimulation Electrophysiological Phenomena Transcranial magnetic stimulation Inhibition Psychological Intracortical facilitation Impulsive Behavior Facilitation Intracortical inhibition Female medicine.symptom business Neuroscience Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Behavioural Brain Research. 407:113266 |
| ISSN: | 0166-4328 |
| Popis: | The ability of motor-inhibitory control is important in daily life. Inhibitory control deficits are commonly observed in psychiatric conditions with enhanced impulsivity. The physiological mechanisms underlying the inhibitory control deficits are not well elucidated. We systematically investigated the relationship between resting-state intracortical inhibition or facilitation and inhibitory control (indicated by stop signal reaction time, SSRT) to determine whether reduced intracortical inhibition or increased intracortical facilitation was related to the poorer inhibitory control. Thirty-three healthy subjects (age: 21.46 ± 1.40 years) participated in this study. We used paired-pulse transcranial magnetic stimulation to induce short intracortical inhibition, intracortical facilitation, long intracortical inhibition, and short intracortical facilitation at rest. SSRT was derived from stop signal task. We performed all measurements in two repeat sessions conducted two weeks apart. A negative correlation between short intracortical inhibition and SSRT was only observed in session 1; however, the correlation did not persist after controlling for short intracortical facilitation. Positive correlation between short intracortical facilitation and SSRT was observed in both sessions, indicating that individuals with greater resting-state short intracortical facilitation tend to have less efficient stopping performance. Our results help explain the inconsistency with respect to the relationship between short intracortical inhibition and SSRT in the existing literature. Short intracortical facilitation may be used as a potential physiological biomarker for motor-inhibitory control, which may have clinical implications for disorders associated with inhibitory control deficits. |
| Databáze: | OpenAIRE |
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