Oxidative instability of boronic acid-installed polycarbonate nanoparticles
| Autor: | Diogo Pessoa, Elena Alexandra Garcia, Margarita Herrera-Alonso |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
inorganic chemicals
Polymers 02 engineering and technology Oxidative phosphorylation 010402 general chemistry medicine.disease_cause 01 natural sciences chemistry.chemical_compound Oxazines medicine Hydrogen peroxide Fluorescent Dyes chemistry.chemical_classification Reactive oxygen species Polycarboxylate Cement Hydrogen Peroxide General Chemistry Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Condensed Matter Physics Boronic Acids 0104 chemical sciences chemistry Delayed-Action Preparations Critical micelle concentration Drug delivery Biophysics Nanoparticles Nanocarriers 0210 nano-technology Oxidation-Reduction Boronic acid Oxidative stress |
| Zdroj: | Soft Matter. 16:2473-2479 |
| ISSN: | 1744-6848 1744-683X |
| Popis: | Oxidative stress, caused by the overproduction of reactive oxygen species (ROS), is often observed in degenerative and/or metabolic diseases, tumors, and inflamed tissues. Boronic acids are emerging as a unique class of responsive biomaterials targeting ROS because of their reactivity toward H2O2. Herein, we examine the oxidative reactivity of nanoparticles from a boronic acid-installed polycarbonate. The extent of oxidation under different concentrations of H2O2 was tracked by the change in fluorescence intensity of an encapsulated solvatochromic reporter dye, demonstrating their sensitivity to biologically-relevant concentrations of hydrogen peroxide. Oxidation-triggered particle destabilization, however, was shown to be highly dependent on the concentration of the final oxidized polymer product, and was only achieved if it fell below polymer critical micelle concentration. Our results indicate that these nanocarriers serve as an excellent dual pH/H2O2 responsive vehicle for drug delivery. |
| Databáze: | OpenAIRE |
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