CD163 as a Potential Biomarker of Monocyte Activation in Ischemic Stroke Patients

Autor: Chiara Demartini, Alessandra Persico, Elena Tumelero, Anna Maria Zanaboni, Cristina Tassorelli, Elisa Candeloro, Andrea Morotti, Rosaria Greco, Diana Amantea
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
peripheral blood monocytes
Severity of Illness Index
Monocytes
Biology (General)
Stroke
Spectroscopy
Aged
80 and over
Interleukin
hemic and immune systems
General Medicine
Middle Aged
Computer Science Applications
Chemistry
medicine.anatomical_structure
B7-1 Antigen
Female
medicine.medical_specialty
acute ischemic stroke
QH301-705.5
CD14
Antigens
Differentiation
Myelomonocytic
Receptors
Cell Surface
chemical and pharmacologic phenomena
CD16
GPI-Linked Proteins
Catalysis
Article
Inorganic Chemistry
Antigens
CD
Internal medicine
medicine
Humans
Physical and Theoretical Chemistry
Molecular Biology
QD1-999
Aged
Ischemic Stroke
business.industry
Monocyte
Organic Chemistry
Receptors
IgG
CD163+
Case-control study
medicine.disease
cytokines
Endocrinology
Cross-Sectional Studies
Case-Control Studies
CD80+
business
CD163
CD80
Biomarkers
Zdroj: International Journal of Molecular Sciences
Volume 22
Issue 13
International Journal of Molecular Sciences, Vol 22, Iss 6712, p 6712 (2021)
ISSN: 1422-0067
DOI: 10.3390/ijms22136712
Popis: In ischemic stroke patients, a higher monocyte count is associated with disease severity and worse prognosis. The complex correlation between subset phenotypes and functions underscores the importance of clarifying the role of monocyte subpopulations. We examined the subtype-specific distribution of the CD163+ and CD80+ circulating monocytes and evaluated their association with the inflammatory status in 26 ischemic stroke patients and 16 healthy controls. An increased percentage of CD163+/CD16+ and CD163+/CD14++ events occurred 24 and 48 h after a stroke compared to the controls. CD163+ expression was more pronounced in CD16+ non-classical and intermediate monocytes, as compared to CD14+ classical subtype, 24 h after stroke. Conversely, the percentage of CD80+/CD16+ events was unaffected in patients
meanwhile, the percentage of CD80+/CD14+ events significantly increased only 24 h after stroke. Interleukin (IL)-1beta, TNF-alpha, and IL-4 mRNA levels were higher, while IL-10 mRNA levels were reduced in total monocytes from patients versus controls, at either 24 h or 48 h after stroke. The percentage of CD163+/CD16+ events 24 h after stroke was positively associated with NIHSS score and mRS at admission, suggesting that stroke severity and disability are relevant triggers for CD163+ expression in circulating CD16+ monocytes.
Databáze: OpenAIRE
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