Expression and regulation of Runx3 in mouse uterus during the peri-implantation period
| Autor: | Xue-Chao Tian, Zhi-Kun Bai, Hang Cao, Shou-Tang Wang, Bin Guo, Zhan-Peng Yue, Qu-Yuan Wang, Dang-Dang Li |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Histology Stromal cell Physiology medicine.drug_class Ovariectomy Uterus Gestational Age In situ hybridization Biology Mice Pregnancy Internal medicine medicine Decidua Animals Decidual cells Blastocyst Embryo Implantation RNA Messenger In Situ Hybridization Progesterone Decidualization Estrogens Cell Biology General Medicine digestive system diseases medicine.anatomical_structure Endocrinology Core Binding Factor Alpha 3 Subunit Gene Expression Regulation Estrogen Ovariectomized rat Female Stromal Cells |
| Zdroj: | Journal of molecular histology. 44(5) |
| ISSN: | 1567-2387 |
| Popis: | The aim of this study was to investigate the differential expression and regulation of Runt-related transcription factor 3 (Runx3) in mouse uterus during early pregnancy and its regulation by steroid hormones using in situ hybridization. There was a low level of the Runx3 mRNA expression in the mouse uterus on days 1–4 of pregnancy. On day 5 when embryo implanted, Runx3 mRNA signal was obviously observed in the stromal cells surrounding the implanting blastocyst. From day 6 to 8 of pregnancy, Runx3 mRNA was highly expressed in the decidual cells and mesometrial decidual beds. Similarly, Runx3 mRNA was strongly expressed in decidualized cells under artificial decidualization. Compared with the delayed uterus, a high level of Runx3 mRNA signal was detected in the uterus with activated implantation. In the ovariectomized mouse uterus, estrogen could induce the expression of Runx3, while progesterone had no effects. These results suggest that Runx3 may play an important role during mouse implantation and decidualization. Estrogen can induce the expression of Runx3 in the ovariectomized mouse uterus. |
| Databáze: | OpenAIRE |
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