Synthesis and antiinflammatory activity of 1,5-diarylimidazoles

Autor:	Kwang-Seog Sin, Hyun Pyo Kim, Haeil Park, Truong Ngoc Tuyen
Rok vydání:	2005
Předmět:	Cyanide Organic Chemistry TosMIC Pharmacology toxicology Anti-Inflammatory Agents Imidazoles Catalysis Cell Line chemistry.chemical_compound Mice chemistry Drug Discovery Molecular Medicine Imidazole Organic chemistry Animals
Zdroj:	Archives of pharmacal research. 28(9)
ISSN:	0253-6269
Popis:	A number of 1,5-diarylimidazoles has been synthesized and evaluated for their inhibitory activities of COX-2 catalyzed PGE2 production. 1,5-Diarylimidazoles were obtained from imimes andp-toluenesulfonylmethyl cyanide (TosMIC). Imines were prepared from commercially available amines and aldehydes. Among the compounds tested, 1-(2,4-difluorophenyl)-5-(4-methylsulfonylphenyl) imidazole (2r) showed strong inhibitory activity, however, most diarylimidazoles exhibited little to low inhibitory activities against COX-2 catalyzed PGE2 production.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29e15eacb6d2d4583826052b34cc7dc https://pubmed.ncbi.nlm.nih.gov/16212229 Zobrazit plný text záznamu Full text from SpringerLink