Translational control in neurovascular brain development
| Autor: | Sofia Bellou, Theodore Fotsis, Kleanthi Chalkiadaki, Maria Markou, Carol Murphy, Eleni Bagli, Elpida Statoulla, Christos G. Gkogkas |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cell type
Multidisciplinary Brain development neurovascular Science Master regulator translational control neurons brain development Human brain Biology endothelial cells medicine.anatomical_structure Precursor cell Gene expression medicine Premovement neuronal activity Biochemistry Cellular and Molecular Biology Process (anatomy) Neuroscience Review Articles |
| Zdroj: | Royal Society Open Science, Vol 8, Iss 10 (2021) Royal Society Open Science |
| ISSN: | 2054-5703 |
| Popis: | The human brain carries out complex tasks and higher functions and is crucial for organismal survival, as it senses both intrinsic and extrinsic environments. Proper brain development relies on the orchestrated development of different precursor cells, which will give rise to the plethora of mature brain cell-types. Within this process, neuronal cells develop closely to and in coordination with vascular cells (endothelial cells (ECs), pericytes) in a bilateral communication process that relies on neuronal activity, attractive or repulsive guidance cues for both cell types and on tight-regulation of gene expression. Translational control is a master regulator of the gene-expression pathway and in particular for neuronal and ECs, it can be localized in developmentally relevant (axon growth cone, endothelial tip cell) and mature compartments (synapses, axons). Herein, we will review mechanisms of translational control relevant to brain development in neurons and ECs in health and disease. |
| Databáze: | OpenAIRE |
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