Vigabatrin therapy implicates neocortical high frequency oscillations in an animal model of infantile spasms
| Autor: | John T. Le, Richard A. Hrachovy, James D. Frost, Carlos J. Ballester-Rosado, Chong L. Lee, John W. Swann |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_treatment Neocortex Electroencephalography Vigabatrin Article lcsh:RC321-571 Temporal lobe Epilepsy Anticonvulsant medicine Animals Humans Ictal lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Brain Mapping Hypsarrhythmia medicine.diagnostic_test Infant West syndrome medicine.disease Rats nervous system diseases body regions Disease Models Animal stomatognathic diseases medicine.anatomical_structure Neurology Anesthesia HFOs Anticonvulsants medicine.symptom Psychology Spasms Infantile medicine.drug |
| Zdroj: | Neurobiology of Disease, Vol 82, Iss, Pp 1-11 (2015) |
| ISSN: | 0969-9961 |
| Popis: | Abnormal high frequency oscillations (HFOs) in EEG recordings are thought to be reflections of mechanisms responsible for focal seizure generation in the temporal lobe and neocortex. HFOs have also been recorded in patients and animal models of infantile spasms. If HFOs are important contributors to infantile spasms then anticonvulsant drugs that suppress these seizures should decrease the occurrence of HFOs. In experiments reported here, we used long-term video/EEG recordings with digital sampling rates capable of capturing HFOs. We tested the effectiveness of vigabatrin (VGB) in the TTX animal model of infantile spasms. VGB was found to be quite effective in suppressing spasms. In 3 of 5 animals, spasms ceased after a daily two week treatment. In the other 2 rats, spasm frequency dramatically decreased but gradually increased following treatment cessation. In all animals, hypsarrhythmia was abolished by the last treatment day. As VGB suppressed the frequency of spasms, there was a decrease in the intensity of the behavioral spasms and the duration of the ictal EEG event. Analysis showed that there was a burst of high frequency activity at ictal onset, followed by a later burst of HFOs. VGB was found to selectively suppress the late HFOs of ictal complexes. VGB also suppressed abnormal HFOs recorded during the interictal periods. Thus VGB was found to be effective in suppressing both the generation of spasms and hypsarrhythmia in the TTX model. Vigabatrin also appears to preferentially suppress the generation of abnormal HFOs, thus implicating neocortical HFOs in the infantile spasms disease state. |
| Databáze: | OpenAIRE |
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