Subclinical atherosclerosis in children and adolescents with congenital heart disease
| Autor: | Yara Maria Franco Moreno, Michele Honicky, Silvia Meyer Cardoso, Matheus A Pacheco, Luiz Rodrigo Augustemak de Lima, Isabela de Carlos Back |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Carotid Artery Diseases Heart Defects Congenital medicine.medical_specialty Waist Heart disease Adolescent 030204 cardiovascular system & hematology Carotid Intima-Media Thickness 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Medicine Humans cardiovascular diseases 030212 general & internal medicine Risk factor Child business.industry Surrogate endpoint General Medicine Odds ratio medicine.disease Atherosclerosis Confidence interval Cardiac surgery Blood pressure Cross-Sectional Studies Pediatrics Perinatology and Child Health Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiology in the young. 31(4) |
| ISSN: | 1467-1107 1047-9511 |
| Popis: | Background:Subclinical atherosclerosis in childhood can be evaluated by carotid intima-media thickness, which is considered a surrogate marker for atherosclerotic disease in adulthood. The aims of this study were to evaluate carotid intima-media thickness and, to investigate associated factors.Methods:Cross-sectional study with children and adolescents with congenital heart disease (CHD). Socio-demographic and clinical characteristics were assessed. Subclinical atherosclerosis was evaluated by carotid intima-media thickness. Cardiovascular risk factors, such as physical activity, screen time, passive smoke, systolic and diastolic blood pressure, waist circumference, dietary intake, lipid parameters, glycaemia, and C-reactive protein, were also assessed. Factors associated with carotid intima-media thickness were analysed using multiple logistic regression.Results:The mean carotid intima-media thickness was 0.518 mm and 46.7% had subclinical atherosclerosis (carotid intima-media thickness ≥ 97th percentile). After adjusting for confounding factors, cyanotic CHD (odds ratio: 0.40; 95% confidence interval: 0.20; 0.78), cardiac surgery (odds ratio: 3.17; 95% confidence interval: 1.35; 7.48), and be hospitalised to treat infections (odds ratio: 1.92; 95% confidence interval: 1.04; 3.54) were associated with subclinical atherosclerosis.Conclusion:Clinical characteristics related to CHD were associated with subclinical atherosclerosis. This finding suggests that the presence of CHD itself is a risk factor for subclinical atherosclerosis. Therefore, the screen and control of modifiable cardiovascular risk factors should be made early and intensively to prevent atherosclerosis. |
| Databáze: | OpenAIRE |
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