Corticosteroid-Sparing Effect of Chromoglycate Sodium and Nedocromil
| Autor: | M. Miraglia del Giudice, A. F. Capristo, C. Alfaro, Nunzia Maiello |
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| Rok vydání: | 1994 |
| Předmět: |
Nedocromil
Pediatrics medicine.medical_specialty medicine.drug_class Immunology Provocation test chemistry.chemical_compound lcsh:Pathology medicine Asthma Inhalation business.industry Cell Biology respiratory system medicine.disease Crossover study respiratory tract diseases Deflazacort chemistry Anesthesia Corticosteroid business Histamine lcsh:RB1-214 Research Article medicine.drug |
| Zdroj: | Mediators of Inflammation Mediators of Inflammation, Vol 3, Iss 7, Pp S25-S30 (1994) |
| ISSN: | 1466-1861 0962-9351 |
| DOI: | 10.1155/s0962935194000712 |
| Popis: | The most appropiate management for bronchial asthma is the control of airway inflammation. Corticosteroids are the most effective anti-inflammatory drugs available, but they have a number of side effects; most of these are dose-dependent. In children, asthma control should be accomplished with low steroid doses possibly given by inhalation. In a double-bind placebo-controlled crossover study a group of children with mild to moderate asthma received NED 16 mg/day or BDP 400 μg/day. Values for FEV1, PEF, symptoms use ofbronchodilators overlapped, whereas bronchial hyper-responsiveness assessed by histamine bronchoprovocation challenge was better with BDP than NED. In another case, one boy with high bronchial hyper-reactivity assessed by provocation test with hypertonic solution, experienced a significant improvement only after 2 weeks of therapy with Deflazacort (2 mg/Kg/day) followed by 4 months on combined treatment with NED (16 mg/day) and BDP (300 μ/day). Authors conclude that NED could have a steroidsparing effect over long-term use. |
| Databáze: | OpenAIRE |
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