Single nucleotide polymorphism rs4284505 in microRNA17 and risk of dental fluorosis
| Autor: | Zerrin Abbasoglu, Letícia Maíra Wambier, Paula Cristina Trevilatto, João Armando Brancher, Rafaela Scariot, Erika Calvano Küchler, Giovana Daniela Pecharki, Flares Baratto-Filho, Kesly Mary Ribeiro Andrades, Mariana Dalledone |
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| Rok vydání: | 2020 |
| Předmět: |
Genetics
Fluorosis Dental Genotype Single-nucleotide polymorphism 030206 dentistry General Medicine Biology medicine.disease Polymorphism Single Nucleotide MicroRNAs stomatognathic diseases 03 medical and health sciences Phenotype 0302 clinical medicine medicine Humans SNP lipids (amino acids peptides and proteins) Child General Dentistry Gene Alleles 030217 neurology & neurosurgery Dental fluorosis |
| Zdroj: | Acta Odontologica Scandinavica. 78:463-466 |
| ISSN: | 1502-3850 0001-6357 |
| DOI: | 10.1080/00016357.2020.1786600 |
| Popis: | The aim of this study is to evaluate the association between the single nucleotide polymorphism (SNP) rs4284505 within the gene that codifies microRNA17 (miRNA17) and dental fluorosis (DF) in a group of children.Children living in a city with fluoridation of public water supplies were included. DF was assessed in erupted permanent teeth by Dean's modified index. The miR-SNP rs4284505 was selected in miRNA17 and genotyping was carried out by real-time PCR. Genotype and allelic distributions between DF and control, and between DF phenotypes (mild, moderate and severe) and control were analysed.Among a total of 527 children enrolled for the study, 383 were DF free and 144 presented DF. In the dominant model analysis (AA + AGThe miR-SNP rs4284505 in miRNA17 was associated with an increased risk of DF. |
| Databáze: | OpenAIRE |
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