Put a ring on it: application of small aliphatic rings in medicinal chemistry
| Autor: | Jennifer E. Nelson, Simon C. C. Lucas, Iacovos N Michaelides, Matthias R. Bauer, Benjamin C Whitehurst, R. Ian Storer, Paolo Di Fruscia |
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| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Cyclobutanes Bicyclic molecule 010405 organic chemistry Chemistry Organic Chemistry Pharmaceutical Science Pentanes Metabolic stability 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound Drug Discovery Molecular Medicine |
| Zdroj: | RSC Med Chem |
| ISSN: | 2632-8682 |
| DOI: | 10.1039/d0md00370k |
| Popis: | Aliphatic three- and four-membered rings including cyclopropanes, cyclobutanes, oxetanes, azetidines and bicyclo[1.1.1]pentanes have been increasingly exploited in medicinal chemistry for their beneficial physicochemical properties and applications as functional group bioisosteres. This review provides a historical perspective and comparative up to date overview of commonly applied small rings, exemplifying key principles with recent literature examples. In addition to describing the merits and advantages of each ring system, potential hazards and liabilities are also illustrated and explained, including any significant chemical or metabolic stability and toxicity risks. |
| Databáze: | OpenAIRE |
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