Engineering proteins that bind to cell surface carbohydrates
| Autor: | J. Mark Bryant, J. Paul Luzio, Peter W. Taylor |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Clinical Biochemistry
Cell Molecular Sequence Data Carbohydrates Protein Engineering Biochemistry Antibodies medicine Carbohydrate Conformation Humans Amino Acid Sequence chemistry.chemical_classification biology Sequence Homology Amino Acid Polysialic acid Biochemistry (medical) Cell Membrane Proteins General Medicine Protein engineering Carbohydrate medicine.anatomical_structure Enzyme Membrane protein chemistry Carbohydrate Sequence Cell surface carbohydrate biology.protein Carbohydrate Metabolism Antibody Protein Binding |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 266(1) |
| ISSN: | 0009-8981 |
| Popis: | Carbohydrate residues covalently linked to plasma membrane proteins and lipids often provide specific markers at the cell surface. Traditionally such carbohydrate structures have been identified using antibodies and lectins. However problems of affinity and lack of specificity have restricted their usefulness. Protein engineering offers a way round these difficulties. In the case of some specialised cell surface carbohydrate structures, such as polysialic acid, enzymes may be useful analytical tools. Endosialidases specific for polysialic acid have recently been cloned and sequenced. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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