Response to Vaccination against Mumps in Medical Students: Two Doses Are Needed

Autor:	Annamaria Nicolli, Chiara Bertoncello, Maria Luisa Scapellato, Angelo Moretto, Stefano Maso, Andrea Trevisan, Paola Mason
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Adult Male 0301 basic medicine Pediatrics medicine.medical_specialty Students Medical 030106 microbiology Dose-Response Relationship Immunologic medical students Antibodies Viral Microbiology Article health care workers Disease Outbreaks 03 medical and health sciences 0302 clinical medicine Seroepidemiologic Studies Virology medicine Humans 030212 general & internal medicine Mumps vaccination biology business.industry Medical school vaccination QR1-502 Vaccination mumps Infectious Diseases Italy Mumps vaccine Infectious disease (medical specialty) biology.protein Significant response Female Antibody Vaccination against mumps business Measles-Mumps-Rubella Vaccine
Zdroj:	Viruses Volume 13 Issue 7 Viruses, Vol 13, Iss 1311, p 1311 (2021)
ISSN:	1999-4915
DOI:	10.3390/v13071311
Popis:	Mumps is a vaccine-preventable infectious disease diffuse worldwide. The implementation of mumps vaccination reduced largely the spread of infection. On 11,327 Medical School students the prevalence of mumps positive antibodies was evaluated according to dose/doses of vaccine, year of birth and sex. Compliance to mumps vaccine was low in students born before 1990 but increased consistently after this year, above all compliance to two doses, due to the implementation of the vaccine offer. Positivity of mumps antibodies is significantly (p < 0.0001) lower in students vaccinated once (71.2%) compared to those vaccinated twice (85.4%). In addition, students born after 1995, largely vaccinated twice, showed a seropositivity near to 90%. Further, females had a significantly (p < 0.0001) higher proportion of positive antibodies after vaccination than males, both one (74.6% vs. 64.7%) and two doses (86.8% vs. 82.9%). Finally, seropositivity after two vaccine doses remains high (86.1%) even 15 years after the second dose. In conclusion, the research highlighted that vaccination against mumps reaches a good level of coverage only after two doses of vaccine persisting at high levels over 15 years and induces a more significant response in females.
Databáze:	OpenAIRE
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