Layer-by-Layer-Assembled AuNPs-Decorated First-Generation Poly(amidoamine) Dendrimer with Reduced Graphene Oxide Core as Highly Sensitive Biosensing Platform with Controllable 3D Nanoarchitecture for Rapid Voltammetric Analysis of Ultratrace DNA Hybridization
| Autor: | Rengarajan Venkatesan, Huangxian Ju, Abhishek Rai, Venkataraman Dharuman, María Belén Camarada, Rajendiran Rajesh, Yangping Wen, Sudipta Roy Barman, Kumarasamy Jayakumar, M. Maniraj |
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| Rok vydání: | 2018 |
| Předmět: |
Dendrimers
Materials science Metal Nanoparticles 02 engineering and technology Biosensing Techniques 010402 general chemistry Electrochemistry 01 natural sciences law.invention law Dendrimer Polyamines General Materials Science Graphene Layer by layer Poly(amidoamine) DNA Electrochemical Techniques 021001 nanoscience & nanotechnology 0104 chemical sciences Chemical engineering Covalent bond Colloidal gold Graphite Gold 0210 nano-technology Biosensor |
| Zdroj: | ACS applied materialsinterfaces. 10(25) |
| ISSN: | 1944-8252 |
| Popis: | The structure and electrochemical properties of layer-by-layer-assembled gold nanoparticles (AuNPs)-decorated first-generation (G1) poly(amidoamine) dendrimer (PD) with reduced graphene oxide (rGO) core as a highly sensitive and label-free biosensing platform with a controllable three-dimensional (3D) nanoarchitecture for the rapid voltammetric analysis of DNA hybridization at ultratrace levels were characterized. Mercaptopropinoic acid (MPA) was self-assembled onto Au substrate, then GG1PD formed by the covalent functionalization between the amino terminals of G1PD and carboxyl terminals of rGO was covalently linked onto MPA, and finally AuNPs were decorated onto GG1PD by strong physicochemical interaction between AuNPs and −OH of rGO in GG1PD, which was characterized through different techniques and confirmed by computational calculation. This 3D controllable thin-film electrode was optimized and evaluated using [Fe(CN)6]3–/4– as the redox probe and employed to covalently immobilize thiol-functionalized... |
| Databáze: | OpenAIRE |
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