Altered immune response in adult women exposed to diethylstilbestrol in utero
| Autor: | Roselynn A. Dynesius-Trentham, Margot Segall-Blank, David E. Trentham, Joseph F. Mortola, Carlos Lorenzo, Louis Burke |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Interleukin 2 medicine.medical_specialty medicine.drug_class T-Lymphocytes media_common.quotation_subject Diethylstilbestrol Tritium Immune system Pregnancy Internal medicine Concanavalin A medicine Humans Prospective Studies Phytohemagglutinins Cells Cultured Menstrual cycle media_common Autoimmune disease Immunity Cellular business.industry Immunity Obstetrics and Gynecology medicine.disease Endocrinology In utero Estrogen Prenatal Exposure Delayed Effects Interleukin-2 Female Immunocompetence business Cell Division Thymidine medicine.drug |
| Zdroj: | American Journal of Obstetrics and Gynecology. 185:78-81 |
| ISSN: | 0002-9378 |
| Popis: | OBJECTIVE: Between 1940 and 1970, 1.5 million female fetuses were exposed to diethylstilbestrol in utero. Numerous deleterious effects on reproductive anatomic and physiologic characteristics have been documented in these women. However, the effects of this exposure on nonreproductive systems, which may have lifelong consequences as this cohort of women progresses beyond the childbearing years, have received little attention. On the basis of an earlier preliminary observation of altered immune reponse, we hypothesized that diethylstilbestrol-exposed women may show abnormalities in T-cell-mediated immune response. STUDY DESIGN: Thirteen women exposed to diethylstilbestrol in utero were compared with 13 age- and menstrual cycle phase-matched control subjects with respect to the in vitro T-cell response to the mitogens phytohemagglutinin, concanavalin A, and interleukin 2. RESULTS: As compared with controls, tritiated thymidine incorporation by T cells harvested from diethylstilbestrol-exposed women was increased 3-fold over a range of concentrations in response to concanavalin A (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect