Clinical Presentation and Outcomes of Middle East Respiratory Syndrome in the Republic of Korea
| Autor: | Seong Yeon Park, Kyungmin Huh, Hye Ok Kim, Hyuck Lee, Yonjae Kim, Jae Hoon Lee, Hyun Kyun Ki, Joon Young Song, Ji Hwan Bang, Gayeon Kim, Yang Ree Kim, Baek-Nam Kim, Nam Joong Kim, Kkot Sil Lee, Won Sup Oh, Shin Woo Kim, Hyoung Shik Shin, Cheol-In Kang, Ji Hyun Yoon, Jin Soo Lee, Sook-In Jung, Kyung Mok Sohn, Won Suk Choi, Jae-Phil Choi, Joon Sung Joh, Doo Ryeon Chung, Ji-Young Rhee, Heungjeong Woo, Yu Mi Wi, Mi Kyong Joung, Eu Suk Kim, Kyong Ran Peck, Hye Won Jeong, Yeon Sook Kim, Sook Hee Song, Young Hyun Lee, Chang-Seop Lee, Younghee Jung, Su Jin Jeong, Sun Hee Lee, Jacob Lee, Young Hwa Choi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty 2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 030106 microbiology 03 medical and health sciences 0302 clinical medicine Peninsula Republic of Korea medicine Pharmacology (medical) 030212 general & internal medicine geography geography.geographical_feature_category business.industry Middle East respiratory syndrome Outbreak medicine.disease humanities Infectious Diseases Original Article Presentation (obstetrics) business |
| Zdroj: | Infection & Chemotherapy |
| ISSN: | 2092-6448 2093-2340 |
| Popis: | Background From May to July 2015, the Republic of Korea experienced the largest outbreak of Middle East respiratory syndrome (MERS) outside the Arabian Peninsula. A total of 186 patients, including 36 deaths, had been diagnosed with MERS-coronavirus (MERS-CoV) infection as of September 30th, 2015. Materials and Methods We obtained information of patients who were confirmed to have MERS-CoV infection. MERS-CoV infection was diagnosed using real-time reverse-transcriptase polymerase chain reaction assay. Results The median age of the patients was 55 years (range, 16 to 86). A total of 55.4% of the patients had one or more coexisting medical conditions. The most common symptom was fever (95.2%). At admission, leukopenia (42.6%), thrombocytopenia (46.6%), and elevation of aspartate aminotransferase (42.7%) were observed. Pneumonia was detected in 68.3% of patients at admission and developed in 80.8% during the disease course. Antiviral agents were used for 74.7% of patients. Mechanical ventilation, extracorporeal membrane oxygenation, and convalescent serum were employed for 24.5%, 7.1%, and 3.8% of patients, respectively. Older age, presence of coexisting medical conditions including diabetes or chronic lung disease, presence of dyspnea, hypotension, and leukocytosis at admission, and the use of mechanical ventilation were revealed to be independent predictors of death. Conclusion The clinical features of MERS-CoV infection in the Republic of Korea were similar to those of previous outbreaks in the Middle East. However, the overall mortality rate (20.4%) was lower than that in previous reports. Enhanced surveillance and active management of patients during the outbreak may have resulted in improved outcomes. |
| Databáze: | OpenAIRE |
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