Pre-Treatment Tumor Expression of ERCC1 in Women with Advanced Stage Epithelial Ovarian Cancer is Not Predictive of Clinical Outcomes: A Gynecologic Oncology Group Study
| Autor: | Michael J. Birrer, Laura J. Niedernhofer, Deborah K. Armstrong, Chunqiao Tian, Jennifer M. Rubatt, Kathleen M. Darcy, Julie A. DeLoia, Thomas C. Krivak, Franco M. Muggia, Michael A. Bookman, Rajiv Dhir |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
endocrine system diseases Genotype Paclitaxel medicine.medical_treatment Gynecologic oncology Carcinoma Ovarian Epithelial Polymorphism Single Nucleotide Article Disease-Free Survival Carboplatin Young Adult Predictive Value of Tests Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Biomarkers Tumor Humans Neoplasms Glandular and Epithelial Aged Neoplasm Staging Randomized Controlled Trials as Topic Aged 80 and over Ovarian Neoplasms Chemotherapy Paraffin Embedding business.industry Obstetrics and Gynecology DNA Neoplasm Middle Aged medicine.disease Endonucleases Combined Modality Therapy Immunohistochemistry female genital diseases and pregnancy complications DNA-Binding Proteins Oncology Predictive value of tests Cancer research Biomarker (medicine) Female ERCC1 Cisplatin Ovarian cancer business Nucleotide excision repair |
| Popis: | Excision repair cross-complementation group 1 (ERCC1) is required for the repair of platinum-induced DNA damage. This study sought to assess the prognostic value of ERCC1 expression, measured by immunohistochemistry (IHC) using a highly specific antibody, in advanced epithelial ovarian cancer (EOC) patients treated with platinum-based chemotherapy.Formalin-fixed, paraffin-embedded tumors were collected from two GOG phase III trials (GOG-172 and GOG-182) of patients with stage III/IV EOC treated with platinum-based chemotherapy. ERCC1 was detected by (IHC) using FL297 polyclonal antibody and tumors were categorized as negative or positive, based on nuclear staining of tumor cells. ERCC1 genotyping was performed as previously reported. Associations between ERCC1 expression and clinical characteristics, platinum responsiveness, progression-free survival (PFS) or overall survival (OS) were evaluated.Of 408 eligible patients, 27% had tumors that were ERCC1 positive. ERCC1 expression was not associated with clinical characteristics or platinum-responsiveness. Women with ERCC1-positive versus -negative tumors had similar median PFS (17.9 months versus 17.5 months, respectively, p=0.59), median OS (52.0 months versus 47.0 months, respectively, p=0.30), risk of disease progression (adjusted hazard ratio [HR]=0.90, 95% confidence interval (CI): 0.71-1.15, p=0.41), and risk of death (adjusted HR=0.81, 95% CI: 0.61-1.07, p=0.14). ERCC1 expression, as measured by IHC, was not associated with single nucleotide polymorphisms (SNPs), in codon 118 and C8092A, of the ERCC1 gene.ERCC1 expression, measured by IHC in pre-treatment tumor specimens, using a highly specific antibody, has limited clinical value in patients with advanced EOC treated with platinum and taxane based chemotherapy. |
| Databáze: | OpenAIRE |
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