Improving overall health of children living with HIV through an oral health intervention in Cambodia: study protocol for a randomized controlled trial

Autor: Makoto Murayama, Chantheany Huot, Pheak Chhoun, Sumiyo Okawa, Sovannary Tuot, Sokunthea Yem, Siyan Yi, Junko Yasuoka, Kimiyo Kikuchi
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Time Factors
Health Status
Child Health Services
Psychological intervention
Human immunodeficiency virus (HIV)
Medicine (miscellaneous)
HIV Infections
Oral Health
Oral care
medicine.disease_cause
law.invention
Study Protocol
0302 clinical medicine
Randomized controlled trial
law
Community-based
Medicine
Pharmacology (medical)
Child
Dental Care for Children
Randomized Controlled Trials as Topic
education.field_of_study
lcsh:R5-920
Age Factors
Treatment Outcome
Caregivers
Child
Preschool
Randomized controlled trials
Female
Cambodia
lcsh:Medicine (General)
Toothbrushing
medicine.medical_specialty
Adolescent
Population
Oral health
Dental Devices
Home Care
03 medical and health sciences
Acquired immunodeficiency syndrome (AIDS)
Patient Education as Topic
030225 pediatrics
Intervention (counseling)
Humans
education
Protocol (science)
business.industry
HIV
030206 dentistry
medicine.disease
Oral Hygiene
Self Care
Tooth Diseases
Family medicine
business
Toothpastes
Zdroj: Trials, Vol 19, Iss 1, Pp 1-9 (2018)
Trials
ISSN: 1745-6215
DOI: 10.1186/s13063-018-3047-z
Popis: Background Currently, the number of children living with HIV is the highest ever. This has led to an increased focus on a healthy life expectancy in this population. Improving oral health status may contribute to improved immunity, which could in turn lead to greater overall health in this population. This study aims to evaluate the effectiveness of an oral health intervention in improving oral health and immune status among children living with HIV in Cambodia. Methods A randomized controlled trial will be conducted in Phnom Penh from May 2018 to April 2020. Among 520 dyads of children living with their respective caregivers, half will be randomly allocated to the intervention group and the other half to the control group. Children aged 3–15 years who are currently receiving antiretroviral therapy at the National Pediatric Hospital will be recruited. In addition, 260 HIV-uninfected children (age-matched to the intervention group) will be recruited from the communities. They, together with their caregivers, will comprise the second control group. The main components of the intervention will include oral health education sessions for the children, as well as daily oral self-care under the supervision of their caregivers. The primary study outcome will be the change in oral health status including the number of decayed, missing, or filled permanent teeth, and the secondary outcome will be CD4 count. The effects of the intervention will be assessed by comparing outcome indicators between the children in the intervention and those in the control groups. Discussion This trial will investigate the effects of an oral health intervention on the improvement of oral health and immune status among children living with HIV and determine the differences compared with the control groups. This intervention would encourage the promotion of oral health interventions among children living with HIV and thus contribute to delaying the onset of AIDS. Trial registration Current Controlled Trials, International Standard Randomized Controlled Trial Number Register, ISRCTN15177479. Registered on 17 January 2018. Electronic supplementary material The online version of this article (10.1186/s13063-018-3047-z) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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