Analysis of RT Sequences of Subtype C HIV-Type 1 Isolates from Indian Patients at Failure of a First-Line Treatment According to Clinical and/or Immunological WHO Guidelines
| Autor: | Patricia Pinson, Alaka Deshpande, Anne Cecile Jeannot, Linda Wittkop, Marie Hélène Schrive, Hervé Fleury |
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| Rok vydání: | 2010 |
| Předmět: |
Cyclopropanes
Anti-HIV Agents Molecular Sequence Data Immunology Human immunodeficiency virus (HIV) India HIV Infections Drug resistance medicine.disease_cause Polymorphism Single Nucleotide Virus Pharmacotherapy Drug Resistance Multiple Viral immune system diseases Virology Genotype medicine Humans Nevirapine Treatment Failure Gene biology virus diseases biology.organism_classification HIV Reverse Transcriptase Reverse transcriptase Benzoxazines Stavudine Infectious Diseases Lamivudine Alkynes Lentivirus HIV-1 Drug Therapy Combination Zidovudine |
| Zdroj: | AIDS Research and Human Retroviruses. 26:343-350 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2009.0217 |
| Popis: | The reverse transcriptase (RT) sequences of HIV-1 subtype C isolates from Indian patients at failure (according to WHO clinical or immunological criteria) of a first-line treatment including d4T/AZT-3TC-NVP/EFV were compared to those of HIV-1 isolates from naive patients and analyzed for drug resistance mutations (DRMs), which were interpreted according to ANRS and Stanford algorithms. All viruses were of subtype C. We have observed a decrease of the polymorphism at positions 36 and 214 of RT while D121Y, V179I, and Q217E could be new DRMs. Numerous crucial DRMs to NRTIs and NNRTIs could be recorded including TAMs of pathway 1 and K65R. According to both algorithms, the accumulation of DRMs may induce resistance to second-line NRTIs including tenofovir. |
| Databáze: | OpenAIRE |
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