PET of serotonin 1A receptors and cerebral glucose metabolism for temporal lobectomy
| Autor: | John D. Heiss, Ashley R. Martinez, William H. Theodore, Omar I. Khan, Clarissa J. Liew, Sungyoung Auh, Irene Dustin, Susumu Sato |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_treatment Electroencephalography Serotonin 5-HT1 Receptor Antagonists Neurosurgical Procedures Piperazines Article Temporal lobe Text mining Cyclohexanes Fluorodeoxyglucose F18 medicine Humans Radiology Nuclear Medicine and imaging Ictal Anterior temporal lobectomy Retrospective Studies medicine.diagnostic_test business.industry Magnetic resonance imaging Retrospective cohort study Magnetic Resonance Imaging Temporal Lobe Glucose Positron emission tomography Anesthesia Positron-Emission Tomography Receptor Serotonin 5-HT1A Female business Nuclear medicine |
| Zdroj: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 53(9) |
| ISSN: | 1535-5667 |
| Popis: | The objective of this study was to compare 5-hydroxytryptamine receptor 1A (5-HT1A) PET with cerebral metabolic rate of glucose (CMRglc) PET for temporal lobectomy planning. Methods: We estimated 5-HT1A receptor binding preoperatively with 18F-trans-4-fluoro-N-2-[4-(2-methoxyphenyl) piperazin-1-yl]ethyl-N-(2-pyridyl) cyclohexane carboxamide (18F-FCWAY) PET and CMRglc measurement with 18F-FDG in regions drawn on coregistered MRI after partial-volume correction in 41 patients who had anterior temporal lobectomy with at least a 1-y follow-up. Surgery was tailored to individual preresection evaluations and intraoperative electrocorticography. Mean regional asymmetry values and the number of regions with asymmetry exceeding 2 SDs in 16 healthy volunteers were compared between seizure-free and non–seizure-free patients. 18F-FCWAY but not 18F-FDG and MRI data were masked for surgical decisions and outcome assessment. Results: Twenty-six of 41 (63%) patients seizure-free since surgery had significantly different mesial temporal asymmetries, compared with 15 non–seizure-free patients for both 18F-FCWAY (F1,39 = 5.87; P = 0.02) and 18F-FDG PET (F1,38 = 5.79; P = 0.021). The probability of being seizure-free was explained by both 18F-FDG and 18F-FCWAY PET, but not MRI, with a significant additional 18F-FCWAY effect ( χ 2 2 = 9.8796; P = 0.0072) after the probability of being seizure-free was explained by 18F-FDG. Although MRI alone was not predictive, any combination of 2 lateralizing imaging studies was highly predictive of seizure freedom. Conclusion: Our study provides class III evidence that both 5-HT1A receptor PET and CMRglc PET can contribute to temporal lobectomy planning. Additional studies should explore the potential for temporal lobectomy based on interictal electroencephalography and minimally invasive imaging studies. |
| Databáze: | OpenAIRE |
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