BioSeq-BLM: a platform for analyzing DNA, RNA and protein sequences based on biological language models
| Autor: | Hong-Liang Li, Yi-He Pang, Bin Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Web server
AcademicSubjects/SCI00010 Sequence analysis Protein sequence analysis Biology computer.software_genre Field (computer science) Data sequences Sequence Analysis Protein RNA Precursors Genetics Deoxyribonuclease I Narese/8 Natural Language Processing Models Statistical Sequence Analysis RNA business.industry RNA-Binding Proteins Sequence Analysis DNA DNA-Binding Proteins Intrinsically Disordered Proteins MicroRNAs Narese/24 Methods Online Nucleic Acid Conformation Language model Artificial intelligence business computer Software Natural language processing |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| DOI: | 10.1093/nar/gkab829 |
| Popis: | In order to uncover the meanings of ‘book of life’, 155 different biological language models (BLMs) for DNA, RNA and protein sequence analysis are discussed in this study, which are able to extract the linguistic properties of ‘book of life’. We also extend the BLMs into a system called BioSeq-BLM for automatically representing and analyzing the sequence data. Experimental results show that the predictors generated by BioSeq-BLM achieve comparable or even obviously better performance than the exiting state-of-the-art predictors published in literatures, indicating that BioSeq-BLM will provide new approaches for biological sequence analysis based on natural language processing technologies, and contribute to the development of this very important field. In order to help the readers to use BioSeq-BLM for their own experiments, the corresponding web server and stand-alone package are established and released, which can be freely accessed at http://bliulab.net/BioSeq-BLM/. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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