Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population

Autor:	Masashi Mizokami, Diego Martin Flichman, Alfredo Martínez, María Laura Hulaniuk, Gustavo A Echenique, Sebastián Marciano, Roberto Fernández, Amalia Rojas, Miguel Charre Samman, Nao Nishida, Mariela Caputo, Felix A. Nuñez, Silvia Frias, Ezequiel Ridruejo, Jorgelina L. Blejer, Daniel Corach, Horacio J. Salamone, Takayo Tsuchiura, Leandro Burgos Pratx, Cecilia Vistarini, Claudia D'Amico, Adrián Gadano, Beatriz Ameigeiras, Carlos Remondegui, Katsushi Tokunaga, Sonia Bartoli, Leila Haddad, Fabiana Heinrich, Masaya Sugiyama, Julieta Trinks, Omar Galdame, Susana Ceballos
Rok vydání:	2017
Předmět:	Male 0301 basic medicine Ciencias de la Salud HLA-DP alpha-Chains medicine.disease_cause Linkage Disequilibrium Gene Frequency HLA Antigens Risk Factors Genotype Epidemiology Odds Ratio HBV HLA-DQ beta-Chains HLA-DP beta-Chains Phylogeny NATIVE AMERICAN Molecular Epidemiology virus diseases Middle Aged Host-Pathogen Interactions Female Adult Hepatitis B virus medicine.medical_specialty CIENCIAS MÉDICAS Y DE LA SALUD Genetic genealogy Argentina Single-nucleotide polymorphism HLA-DP Biology Polymorphism Single Nucleotide 03 medical and health sciences Hepatitis B Chronic HLA-DQ Antigens HLA-DQ medicine Humans SNP Aged Chi-Square Distribution Salud Ocupacional Hepatology Protective Factors GENOTYPES Virology digestive system diseases Logistic Models 030104 developmental biology Multivariate Analysis Immunology HLA GENES
Zdroj:	Liver International. 37:1476-1487
ISSN:	1478-3223
Popis:	Background & Aims: HBV infection exhibits geographical variation in its distribution in South America. While HBV rates are low in central Argentina, the north-western region exhibits intermediate HBV rates. Unfortunately, the reasons that could explain this difference are still unknown. Methods: a total of 1440 Argentines were recruited and grouped into HBV patients, HBV-resolved individuals and healthy controls. Genetic ancestry was assessed by analysis of biparental lineages and ancestry autosomal typing. SNPs of HLA-DPA1 (rs3077), HLA-DPB1 (rs9277542), HLA-DQB1 (rs2856718) and HLA-DQB2 (rs7453920) were determined, and HBV genotyping was performed by phylogenetic analysis in HBV patients. Results: Native American ancestry prevailed in the north-western region when compared with central Argentina (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2897b6ed32de7a0f67a2dfd0354f656 https://doi.org/10.1111/liv.13405 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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