An update on head and neck cancer: new entities and their histopathology, molecular background, treatment, and outcome

Autor: Lauge Hjorth Mikkelsen, Simon Andreasen, Irene Wessel, Linea Cecilie Melchior, Katalin Kiss, Christina Caroline Plaschke, Hani Ibrahim Channir, Jesper Grau Eriksen
Rok vydání: 2018
Předmět:
0301 basic medicine
Microbiology (medical)
Oncology
medicine.medical_specialty
Electrochemotherapy
Nose Neoplasms
Histopathology
Oropharyngeal Neoplasms/pathology
Mouth Neoplasms/pathology
World health
Pathology and Forensic Medicine
Surgical pathology
03 medical and health sciences
pathology of tumors
0302 clinical medicine
molecular pathology
Internal medicine
Melanoma/pathology
medicine
Immunology and Allergy
Humans
Molecular Targeted Therapy
Head and neck
Melanoma
Molecular pathology
business.industry
Head and neck cancer
Cancer
General Medicine
Sinonasal Tract
medicine.disease
Prognosis
Salivary Gland Neoplasms
Head and Neck Neoplasms/classification
Oropharyngeal Neoplasms
030104 developmental biology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Mouth Neoplasms
Nose Neoplasms/pathology
business
Salivary Gland Neoplasms/pathology
prognostic markers
surgical pathology
Zdroj: Andreasen, S, Kiss, K, Mikkelsen, L H, Channir, H I, Plaschke, C C, Melchior, L C, Eriksen, J G & Wessel, I 2019, ' An update on head and neck cancer: new entities and their histopathology, molecular background, treatment, and outcome ', APMIS Supplementum, vol. 127, no. 5, pp. 240-264 . https://doi.org/10.1111/apm.12901
ISSN: 1600-0463
DOI: 10.1111/apm.12901
Popis: The head and neck region harbor numerous specialized tissues of all lineages giving rise to a plethora of different malignancies. In recent years, new types and subtypes of cancer has been described here due to the recognition of their histological and molecular characteristics. Some have been formally accepted in the most recent classifications from the World Health Organization (WHO) and American Joint Committee on Cancer (AJCC) as distinct diseases due to characteristics in clinical presentation, outcome, and treatment. In particular, this applies to malignancies of the salivary gland, sinonasal tract, and oropharynx. In this overview, we present the most recent developments in the classification, histopathological characteristics, and molecular features of head and neck cancer. The clinical and radiological characteristics, outcome, and treatment options including perspectives for targeted therapies, are discussed.
Databáze: OpenAIRE
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