Calcineurin inhibitors enhance low-density lipoprotein oxidation in transplant patients
| Autor: | Zac Varghese, Erasmia Psimenou, R Fernando, Gita Turakhia, Paul Sweny, Stephen H. Powis, John F. Moorhead, O. N. Fernando |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male neoral medicine.medical_specialty Time Factors oxidation medicine.medical_treatment Calcineurin Inhibitors chemical and pharmacologic phenomena Ascorbic Acid Tacrolimus chemistry.chemical_compound Internal medicine medicine Humans Urea Vitamin E Lipoprotein oxidation Triglycerides business.industry renal transplantation Middle Aged Ascorbic acid Kidney Transplantation Calcineurin Transplantation Lipoproteins LDL surgical procedures operative Endocrinology Cholesterol chemistry Nephrology Low-density lipoprotein Cyclosporine Density gradient ultracentrifugation Drug Therapy Combination Female business Oxidation-Reduction Immunosuppressive Agents |
| Zdroj: | Kidney international. Supplement. 71 |
| ISSN: | 0098-6577 |
| Popis: | Calcineurin inhibitors enhance low-density lipoprotein oxidation in transplant patients Background Our objective was to assess the pro-oxidant status of neoral and tacrolimus in renal transplant patients and monitor the protection provided by vitamin C and vitamin E in normalizing low density lipoprotein (LDL) oxidation lag time of tacrolimus-treated patients. Methods Plasma LDL was isolated by density gradient ultracentrifugation from renal transplant patients receiving neoral, tacrolimus and tacrolimus with vitamin C and vitamin E. Oxidation was initiated by the addition of CuCl 2 at 37°C and monitored at 234 nm over 480 minutes and oxidation lag time was computed. Total antioxidant capacity of serum was measured using the enhanced chemiluminescent method. Results LDL from tacrolimus-treated patients had significantly lower oxidation lag time and serum antioxidant activity in comparison with neoral-treated patients, and this was particularly significant during the first four months after transplantation. Vitamin C and E supplementation in tacrolimus treated patients provided protection against oxidation and normalized their oxidation lag time. Conclusion Calcineurin-inhibiting drugs, CsA and tacrolimus, have pro-oxidant activity and they increase the susceptibility of LDL to oxidation. Neoral formulation is fortified with DL-α tocopherol and therefore provides protection against oxidation. The present study clearly demonstrates the benefit of giving vitamin C and E supplements to patients taking tacrolimus and this seems to be particularly important during the early period after transplantation. |
| Databáze: | OpenAIRE |
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