Levofloxacin: Insights Into Antibiotic Resistance and Product Quality
| Autor: | Md. Moklesur Rahman Sarker, Kai Bin Liew, Meor Mohd Redzuan Meor Mohd Affandi, Kah Seng Lee, Nurolaini Kifli, Ensieh Izadi, Amal K Suleiman, Gull Afshan, Long Chiau Ming, Rahul P. Patel, Syed Tabish R. Zaidi, Venkatesan M. Rao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Drug medicine.medical_specialty media_common.quotation_subject Mini Review Postmarketing surveillance Bioequivalence 03 medical and health sciences 0302 clinical medicine Levofloxacin medicine counterfeit Pharmacology (medical) Dissolution testing Quality (business) Intensive care medicine media_common Active ingredient Pharmacology business.industry lcsh:RM1-950 quality medicine Counterfeit regulatory requirement 030104 developmental biology lcsh:Therapeutics. Pharmacology 030220 oncology & carcinogenesis post marketing surveillance business fluroquinolone resistance medicine.drug |
| Zdroj: | Frontiers in Pharmacology Frontiers in Pharmacology, Vol 10 (2019) |
| ISSN: | 1663-9812 |
| Popis: | Counterfeit and substandard medicines are recognized as one of serious threats to public health. The product quality of antibacterial medicine will compromise patients' recovery and increase the chance of antibacterial resistance. The review aims to provide a summary of low quality levofloxacin issues and the risk factors as well as suggesting the aspects of product quality that need to be regulated strictly. Quality of the active ingredient, levofloxacin, has an important role to contribute to successful therapy. The poor quality of raw material, directly and indirectly, causes treatment failure as the presence of insufficient dose, mislabeled content, and poor dissolution characteristics can lead to lower bioavailability. Identifying and reporting these factors can potentially help in improving the quality of drug marketed in various developing countries and may also reduce the incidences of treatment failure. Dissolution test is used for testing the dissolution profiles and the rate of drug release from solid formulation such as oral formulations, thus providing information regarding the in vivo performance of a formulation and its bioequivalence. On the other hand, quality-testing procedures are used for comparing the quality of products. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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