Splenic Marginal Zone Lymphoma andConcurrentMembranoproliferative Glomerulonephritis With IgMKappa Deposits in a HCV-Seropositive Patient
| Autor: | Maria Sotiraki, Alexia Papalexandrou, Maria Tsilivigkou, Evdokia Efthimiou, Eleni Chelioti |
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| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test business.industry Biopsy Urology Hepatosplenomegaly Case Report Lymphoma B-Cell Marginal Zone Hepatitis C Kidney medicine.disease Lymphoma Gammopathy Membranoproliferative glomerulonephritis medicine Splenic marginal zone lymphoma Renal biopsy medicine.symptom business Membranoproliferative Glomerulonephritis |
| Zdroj: | Nephro-urology Monthly |
| ISSN: | 2251-7014 2251-7006 |
| Popis: | We report a case of membranoproliferative glomerulonephritis (MPGN) with IgMκ light chain deposits in a patient with chronic hepatitis C infection and simultaneous onset of monoclonal IgMκ gammopathy with concurrent small B-cell lymphoproliferative disease. The patient presented with hepatosplenomegaly and a uremic state that necessitated dialysis without any clinical signs of systemic disease apart from the chronic infection with hepatitis C virus. The diagnostic approach led to a renal biopsy that revealed MPGN with dominant IgMκ deposits and interstitium infiltration by the lymphoid cells. The bone marrow biopsy findings were consistent with splenic marginal zone lymphoma, a rare lymphoproliferative disorder with a rare association with MPGN. Our case indicates high diagnostic value of renal biopsy for rare lymphoplasmacytic neoplasms with renal dysfunction as their predominant clinical manifestation. |
| Databáze: | OpenAIRE |
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