The Cascade System of Osmotic Homeostasis Regulation
| Autor: | E. I. Shakhmatova, A. S. Marina, Yu. V. Natochin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Vasopressin
medicine.medical_specialty Drinking Oxytocin General Biochemistry Genetics and Molecular Biology Excretion 03 medical and health sciences Osmoregulation 0302 clinical medicine Glucagon-Like Peptide 1 Internal medicine medicine Animals Secretion Rats Wistar 0303 health sciences Kidney General Immunology and Microbiology Chemistry Sodium 030302 biochemistry & molecular biology General Medicine medicine.anatomical_structure Endocrinology Potassium Exenatide Calcium General Agricultural and Biological Sciences hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Homeostasis Hormone medicine.drug |
| Zdroj: | Doklady Biological Sciences. 490:5-8 |
| ISSN: | 1608-3105 0012-4966 |
| DOI: | 10.1134/s0012496620010056 |
| Popis: | The human and animal osmoregulation system is aimed at stabilizing serum osmolality in order to maintain cell volume. It has been shown that the introduction of 5 mL water per 100 g of body weight into the stomach of rats decreases serum osmolality and the concentration of Na and Ca, but not K and Mg. The cascade system of osmotic homeostasis increases secretion of glucagon-like peptide-1 (GLP-1) and oxytocin, and decreases secretion of vasopressin, which reduces the osmotic permeability of collecting duct. After water loading and the injection of 0.015 nM exenatide (GLP-1 mimetic), the time of excretion of 50% of water was halved from 112 ± 4 to 57 ± 5 min (p < 0.01), and after the injection of 0.015 nM oxytocin, it decreased to 83 ± 6 min (p < 0.01). The physiological mechanism of renal effect of the aforementioned hormones which accelerate the recovery of osmotic homeostasis has been found. |
| Databáze: | OpenAIRE |
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