Comparative efficacy of oral doses of clindamycin and erythromycin in the prevention of bacteraemia
| Autor: | J. D. Williams, A. Seymour, R A Whiley, C. Kerawala, M Murphy, C Aitken, A. M. Sefton, H. Cannell |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.drug_class Nausea Premedication Antibiotics Erythromycin Bacteremia Microbial Sensitivity Tests medicine.disease_cause Gastroenterology Statistics Nonparametric Double-Blind Method Streptococcal Infections Internal medicine medicine Humans Blood culture General Dentistry Aged Dose-Response Relationship Drug medicine.diagnostic_test Streptococcus business.industry Clindamycin Middle Aged medicine.disease Abdominal Pain stomatognathic diseases Anesthesia Tooth Extraction medicine.symptom business medicine.drug |
| Zdroj: | British Dental Journal. 178:418-422 |
| ISSN: | 1476-5373 0007-0610 |
| DOI: | 10.1038/sj.bdj.4808789 |
| Popis: | Two antibiotics, clindamycin and erythromycin, were compared in a double-blind trial to test their efficacy in the prevention of post-dental extraction bacteraemia with streptococci in a group of 40 healthy patients. Tolerance to the oral doses was tested by questionnaire. Levels of drug in the serum were estimated using a microbiological assay. An in-vitro blood culture system was used as an analogy of the persistence of a bacteraemia in the presence of high levels of antibiotic. Isolates of streptococci were identified to species level. Minimum inhibitory concentrations of clindamycin and of erythromycin for each isolate were estimated. Results showed satisfactory levels of antibiotics in the blood for activity against oral streptococci. Clindamycin was slightly more effective than erythromycin in the prevention of post-extraction streptococcal bacteraemia but that efficacy was only 45%. Clindamycin as a single oral dose of 600 mg was well tolerated by patients compared with erythromycin 1.5 g. |
| Databáze: | OpenAIRE |
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