Mechanisms of the Impact of Hashimoto Thyroiditis on Papillary Thyroid Carcinoma Progression: Relationship with the Tumor Immune Microenvironment
| Autor: | Oleksandr Maievskyi, Olena Chernenko, Yurii Penchuk, Olena Tsyryuk, Oleksiy Selesnov, Oksana Sulaieva, Tetyana Falalyeyeva, Dmytro Shapochka, Oleksandr Nechay, Nazarii Kobyliak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Stromal cell endocrine system diseases Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Pilot Projects lcsh:Diseases of the endocrine glands. Clinical endocrinology T-Lymphocytes Regulatory Metastasis 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Endocrinology Immune system medicine Tumor Microenvironment Humans Thyroid Neoplasms Thyroid cancer T-lymphocytes lcsh:RC648-665 Hashimoto disease business.industry Macrophages FOXP3 Thyroid cancer papillary Middle Aged medicine.disease Prognosis Carcinoma Papillary Vascular endothelial growth factor chemistry 030220 oncology & carcinogenesis Cancer research Disease Progression Original Article Female business CD163 CD8 Follow-Up Studies |
| Zdroj: | Endocrinology and Metabolism Endocrinology and Metabolism, Vol 35, Iss 2, Pp 443-455 (2020) |
| ISSN: | 2093-5978 2093-596X |
| Popis: | Background The relationship between Hashimoto thyroiditis (HT) and papillary thyroid carcinoma (PTC) remains uncertain. We assessed the impact of HT on the tumor immune microenvironment (TIME) in PTC. Methods Thirty patients with PTC (group 1) and 30 patients with PTC and HT (group 2) were enrolled in this pilot study. The distribution and number of CD8+ lymphocytes, plasma cells (CD138+), regulatory T cells (forkhead box P3 [FOXP3+)], mast cell tryptase (MCT+), and M2 macrophages (CD163+) were evaluated. To test the hypothesis that HT impacts PTC development via signal transducer and activator of transcription 6 (STAT6) activation and M2 macrophage polarization, we investigated STAT6 expression in tumor and stromal cells. We also evaluated vascular endothelial growth factor (VEGF) expression by lymph node metastasis (LNM) status. Results TIME showed significant between-group differences. Group 1 patients demonstrated immune desert or immune-excluded immunophenotypes, while an inflamed phenotype with more CD8+ cells (Pl0.001) predominated in group 2. Immune-excluded TIME was associated with the highest LNM rate. In PTC, LNM was associated with more numerous CD163+ cells. Moreover, LNM in group 1 was associated with increased numbers of mast cells peritumorally and FOXP3+ cells intratumorally and peritumorally. Group 2 demonstrated higher STAT6 but not higher VEGF expression in tumor cells. High VEGF expression was associated with LNM regardless of HT status. Conclusion Concomitant HT impacted PTC signaling via STAT6 and TIME by increasing the number of CD8+ cells. LNM is associated with increases in CD163+ cells and VEGF expression in PTC, whereas HT affected LNM through different mechanisms. |
| Databáze: | OpenAIRE |
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