Preadmission Application of 2% Chlorhexidine Gluconate (CHG): Enhancing Patient Compliance While Maximizing Skin Surface Concentrations
| Autor: | Sarah E. Edmiston, Cheong J. Lee, Peter J. Rossi, Brian D. Lewis, Kellie R. Brown, Charles E. Edmiston, Gary R. Seabrook, Michael J. Malinowski, Álvaro Antônio Bandeira Ferraz, Edmundo Machado Ferraz, Candace J. Krepel, Maureen Spencer, David Leaper |
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| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Epidemiology Staphylococcus Antisepsis 030501 epidemiology Preoperative care law.invention Tertiary Care Centers 03 medical and health sciences Minimum inhibitory concentration 0302 clinical medicine Randomized controlled trial law Skin surface Chlorhexidine gluconate Preoperative Care Medicine Humans Surgical Wound Infection 030212 general & internal medicine Patient compliance Volunteer Skin business.industry Chlorhexidine Baths Surgery Infectious Diseases Anesthesia Anti-Infective Agents Local Patient Compliance 0305 other medical science business medicine.drug |
| Zdroj: | Infection control and hospital epidemiology. 37(3) |
| ISSN: | 1559-6834 0899-823X |
| Popis: | OBJECTIVESurgical site infections (SSIs) are responsible for significant morbidity and mortality. Preadmission skin antisepsis, while controversial, has gained acceptance as a strategy for reducing the risk of SSI. In this study, we analyze the benefit of an electronic alert system for enhancing compliance to preadmission application of 2% chlorhexidine gluconate (CHG).DESIGN, SETTING, AND PARTICIPANTSFollowing informed consent, 100 healthy volunteers in an academic, tertiary care medical center were randomized to 5 chlorhexidine gluconate (CHG) skin application groups: 1, 2, 3, 4, or 5 consecutive applications. Participants were further randomized into 2 subgroups: with or without electronic alert. Skin surface concentrations of CHG (μg/mL) were analyzed using a colorimetric assay at 5 separate anatomic sites.INTERVENTIONPreadmission application of chlorhexidine gluconate, 2%RESULTSMean composite skin surface CHG concentrations in volunteer participants receiving EA following 1, 2, 3, 4, and 5 applications were 1,040.5, 1,334.4, 1,278.2, 1,643.9, and 1,803.1 µg/mL, respectively, while composite skin surface concentrations in the no-EA group were 913.8, 1,240.0, 1,249.8, 1,194.4, and 1,364.2 µg/mL, respectively (ANOVA, P90]) for 1, 2, 3, 4, or 5 applications using the 2% CHG cloth were 208.1, 266.8, 255.6, 328.8, and 360.6, respectively, representing CHG skin concentrations effective against staphylococcal surgical pathogens. The use of an electronic alert system resulted in significant increase in skin concentrations of CHG in the 4- and 5-application groups (PPCONCLUSIONThe findings of this study suggest an evidence-based standardized process that includes use of an Internet-based electronic alert system to improve patient compliance while maximizing skin surface concentrations effective against MRSA and other staphylococcal surgical pathogens.Infect. Control Hosp. Epidemiol. 2016;37(3):254–259 |
| Databáze: | OpenAIRE |
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