Assessing the Risk of Nodal Metastases in Canine Integumentary Mast Cell Tumors: Is Sentinel Lymph Node Biopsy Always Necessary?
| Autor: | Martina Manfredi, Roberta Ferrari, D. De Zani, Valeria Grieco, Damiano Stefanello, Patrizia Boracchi, Elisa Maria Gariboldi, Carlotta Spediacci, Camilla Recordati, Chiara Giudice, Lavinia E. Chiti |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty mast cell tumor Veterinary medicine Sentinel lymph node Lower risk Mast cell tumors Article Metastasis sentinel lymph node lymphoscintigraphy Biopsy SF600-1100 medicine metastasis Lymph node General Veterinary medicine.diagnostic_test business.industry Integumentary system staging medicine.disease Occult medicine.anatomical_structure QL1-991 Animal Science and Zoology business Zoology |
| Zdroj: | Animals, Vol 11, Iss 2373, p 2373 (2021) Animals : an Open Access Journal from MDPI Animals Volume 11 Issue 8 |
| ISSN: | 2076-2615 |
| Popis: | The recent literature supports the sentinel lymph node (SLN) biopsy in dogs with MCT due to discrepancy with the regional lymph node and the high percentage of occult metastasis. However, the SLN biopsy includes additional anesthesiologic, diagnostic, and surgical procedures, and additional costs. The study aimed to assess the association between clinicopathological variables and SLN status, determining the identification of dogs at lower risk of SLN metastases. Dogs with integumentary MCT were admitted to the lymphoscintigraphic mapping and subsequent biopsy of SLN. The association between clinicopathological variables of MCT and SLN status was statistically tested, both considering occult and overt metastasis together (HN2-HN3) and overt metastasis (HN3) alone. Fifty low-grade cutaneous MCT and 16 subcutaneous MCT were included. A small to moderate association between integumentary MCT ≥ 3 cm and HN2-HN3 SLN was found. A strong association of integumentary MCT dimension and subcutaneous MCT with HN3 SLN occurred. Dimension of low-grade cutaneous and subcutaneous MCT seems to correlate with SLN status, but additional study should confirm this data before excluding small MCT to the SLN biopsy. On the contrary, the study results induce a solid suggestion for mapping and biopsy of the SLN in MCT > 3 cm and subcutaneous MCT. |
| Databáze: | OpenAIRE |
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